Literature DB >> 1700020

Monoclonal antibodies distinguishing alpha and beta forms of calcitonin gene-related peptide.

D P Andrew1, T D Bidgood, C Bose, D Brown, G Galfre, M Sherwood.   

Abstract

A panel of 18 monoclonal antibodies was raised to the human calcitonin gene related peptide (CGRP). Of these mabs, seven were specific for alpha CGRP and five for beta CGRP, while the remainder reacted with both alpha and beta CGRP. Nine different epitopes on CGRP were defined with these mabs. In addition, the mabs were tested in various combinations to develop a series of two site assays specific for alpha or for beta CGRP as well as assays able to detect both.

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Year:  1990        PMID: 1700020     DOI: 10.1016/0022-1759(90)90115-c

Source DB:  PubMed          Journal:  J Immunol Methods        ISSN: 0022-1759            Impact factor:   2.303


  3 in total

1.  On the role of the C-terminus of alpha-calcitonin-gene-related peptide (alpha CGRP). The structure of des-phenylalaninamide37-alpha CGRP and its interaction with the CGRP receptor.

Authors:  J P O'Connell; S M Kelly; D P Raleigh; J A Hubbard; N C Price; C M Dobson; B J Smith
Journal:  Biochem J       Date:  1993-04-01       Impact factor: 3.857

2.  The effect of monoclonal antibodies to calcitonin gene-related peptide (CGRP) on CGRP-induced vasodilatation in pig coronary artery rings.

Authors:  N E Shaw; R Foulkes; D P Andrew; D T Brown; B Hughes
Journal:  Br J Pharmacol       Date:  1992-05       Impact factor: 8.739

3.  Structural studies on the [Bu(t)-Cys18](19-37)-fragment of human beta-calcitonin-gene-related peptide.

Authors:  J K Sagoo; C Bose; N R Beeley; S J Tendler
Journal:  Biochem J       Date:  1991-11-15       Impact factor: 3.857

  3 in total

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