| Literature DB >> 17000031 |
Xian-Feng Huang1, Ban-Feng Ruan, Xiao-Ting Wang, Chen Xu, Hui-Ming Ge, Hai-Liang Zhu, Ren-Xiang Tan.
Abstract
Eleven C2-substituted derivatives of resveratrol (trans-3,4',5-trihydroxystilbene, RES) were prepared by partial synthesis from RES and evaluated for their cytotoxic activities against a human nasopharyngeal epidermoid tumor cell line KB. Among them, compounds 2 and 3 were more active than 5-fluorouracil (5-FU), an anticancer drug, and compound 5f exhibited similar activity to 5-FU. On the basis of the biological results, structure-activity relationships were discussed.Entities:
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Year: 2006 PMID： 17000031 DOI： 10.1016/j.ejmech.2006.08.006
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514