OBJECTIVE: Although growing interest exists in the bipolar spectrum, fully structured diagnostic interviews might not accurately assess bipolar spectrum disorders. A validity study was carried out for diagnoses of threshold and sub-threshold bipolar disorders (BPD) based on the WHO Composite International Diagnostic Interview (CIDI) in the National Comorbidity Survey Replication (NCS-R). CIDI BPD screening scales were also evaluated. METHOD: The NCS-R is a nationally representative US household population survey (n=9282 using CIDI to assess DSM-IV disorders. CIDI diagnoses were evaluated in blinded clinical reappraisal interviews using the non-patient version of the Structured Clinical Interview for DSM-IV (SCID). RESULTS: Excellent CIDI-SCID concordance was found for lifetime BP-I (AUC=.99 kappa=.88, PPV=.79, NPV=1.0), either BP-II or sub-threshold BPD (AUC=.96, kappa=.88, PPV=.85, NPV=.99), and overall bipolar spectrum disorders (i.e., BP-I/II or sub-threshold BPD; AUC=.99, kappa=.94, PPV=.88, NPV=1.0). Concordance was lower for BP-II (AUC=.83, kappa=.50, PPV=.41, NPV=.99) and sub-threshold BPD (AUC=.73, kappa=.51, PPV=.58, NPV=.99). The CIDI was unbiased compared to the SCID, yielding a lifetime bipolar spectrum disorders prevalence estimate of 4.4%. Brief CIDI-based screening scales detected 67-96% of true cases with positive predictive value of 31-52%. LIMITATION: CIDI prevalence estimates are still probably conservative, though, but might be improved with future CIDI revisions based on new methodological studies with a clinical assessment more sensitive than the SCID to sub-threshold BPD. CONCLUSIONS: Bipolar spectrum disorders are much more prevalent than previously realized. The CIDI is capable of generating conservative diagnoses of both threshold and sub-threshold BPD. Short CIDI-based scales are useful screens for BPD.
OBJECTIVE: Although growing interest exists in the bipolar spectrum, fully structured diagnostic interviews might not accurately assess bipolar spectrum disorders. A validity study was carried out for diagnoses of threshold and sub-threshold bipolar disorders (BPD) based on the WHO Composite International Diagnostic Interview (CIDI) in the National Comorbidity Survey Replication (NCS-R). CIDI BPD screening scales were also evaluated. METHOD: The NCS-R is a nationally representative US household population survey (n=9282 using CIDI to assess DSM-IV disorders. CIDI diagnoses were evaluated in blinded clinical reappraisal interviews using the non-patient version of the Structured Clinical Interview for DSM-IV (SCID). RESULTS: Excellent CIDI-SCID concordance was found for lifetime BP-I (AUC=.99 kappa=.88, PPV=.79, NPV=1.0), either BP-II or sub-threshold BPD (AUC=.96, kappa=.88, PPV=.85, NPV=.99), and overall bipolar spectrum disorders (i.e., BP-I/II or sub-threshold BPD; AUC=.99, kappa=.94, PPV=.88, NPV=1.0). Concordance was lower for BP-II (AUC=.83, kappa=.50, PPV=.41, NPV=.99) and sub-threshold BPD (AUC=.73, kappa=.51, PPV=.58, NPV=.99). The CIDI was unbiased compared to the SCID, yielding a lifetime bipolar spectrum disorders prevalence estimate of 4.4%. Brief CIDI-based screening scales detected 67-96% of true cases with positive predictive value of 31-52%. LIMITATION: CIDI prevalence estimates are still probably conservative, though, but might be improved with future CIDI revisions based on new methodological studies with a clinical assessment more sensitive than the SCID to sub-threshold BPD. CONCLUSIONS:Bipolar spectrum disorders are much more prevalent than previously realized. The CIDI is capable of generating conservative diagnoses of both threshold and sub-threshold BPD. Short CIDI-based scales are useful screens for BPD.
Authors: Robert M A Hirschfeld; Charles Holzer; Joseph R Calabrese; Myrna Weissman; Michael Reed; Marilyn Davies; Mark A Frye; Paul Keck; Susan McElroy; Lydia Lewis; Jonathan Tierce; Karen D Wagner; Elizabeth Hazard Journal: Am J Psychiatry Date: 2003-01 Impact factor: 18.112
Authors: Ronald C Kessler; Patricia Berglund; Olga Demler; Robert Jin; Kathleen R Merikangas; Ellen E Walters Journal: Arch Gen Psychiatry Date: 2005-06
Authors: Ronald C Kessler; Shelli Avenevoli; E Jane Costello; Katholiki Georgiades; Jennifer Greif Green; Michael J Gruber; Jian-ping He; Doreen Koretz; Katie A McLaughlin; Maria Petukhova; Nancy A Sampson; Alan M Zaslavsky; Kathleen Ries Merikangas Journal: Arch Gen Psychiatry Date: 2011-12-05
Authors: A J Rosellini; H Liu; M V Petukhova; N A Sampson; S Aguilar-Gaxiola; J Alonso; G Borges; R Bruffaerts; E J Bromet; G de Girolamo; P de Jonge; J Fayyad; S Florescu; O Gureje; J M Haro; H Hinkov; E G Karam; N Kawakami; K C Koenen; S Lee; J P Lépine; D Levinson; F Navarro-Mateu; B D Oladeji; S O'Neill; B-E Pennell; M Piazza; J Posada-Villa; K M Scott; D J Stein; Y Torres; M C Viana; A M Zaslavsky; R C Kessler Journal: Psychol Med Date: 2017-07-19 Impact factor: 7.723
Authors: E J Bromet; L Atwoli; N Kawakami; F Navarro-Mateu; P Piotrowski; A J King; S Aguilar-Gaxiola; J Alonso; B Bunting; K Demyttenaere; S Florescu; G de Girolamo; S Gluzman; J M Haro; P de Jonge; E G Karam; S Lee; V Kovess-Masfety; M E Medina-Mora; Z Mneimneh; B-E Pennell; J Posada-Villa; D Salmerón; T Takeshima; R C Kessler Journal: Psychol Med Date: 2016-08-30 Impact factor: 7.723
Authors: A A Nierenberg; H S Akiskal; J Angst; R M Hirschfeld; K R Merikangas; M Petukhova; R C Kessler Journal: Mol Psychiatry Date: 2009-06-30 Impact factor: 15.992