AIM: To determine whether concomitant iron affects the absorption of mycophenolate mofetil. METHODS: An open-label, single centre, randomized, crossover trial was conducted in 16 healthy males. Fasting subjects received mycophenolate mofetil alone (treatment A) or co-administered with iron (treatment B). RESULTS: The mycophenolic acid AUC(0,24 h) for treatments A and B were 42.5 +/- 10.5 and 44.7 +/- 12.4 microg ml(-1) h, respectively. anova modelling showed the relative bioavailability of mycophenolate mofetil to be similar for the two treatments (90% confidence interval 0.92, 1.19). CONCLUSIONS: There was no interaction between mycophenolate mofetil and iron supplements administered concomitantly to healthy fasting subjects.
RCT Entities:
AIM: To determine whether concomitant iron affects the absorption of mycophenolate mofetil. METHODS: An open-label, single centre, randomized, crossover trial was conducted in 16 healthy males. Fasting subjects received mycophenolate mofetil alone (treatment A) or co-administered with iron (treatment B). RESULTS: The mycophenolic acid AUC(0,24 h) for treatments A and B were 42.5 +/- 10.5 and 44.7 +/- 12.4 microg ml(-1) h, respectively. anova modelling showed the relative bioavailability of mycophenolate mofetil to be similar for the two treatments (90% confidence interval 0.92, 1.19). CONCLUSIONS: There was no interaction between mycophenolate mofetil and iron supplements administered concomitantly to healthy fasting subjects.
Authors: M Morii; K Ueno; A Ogawa; R Kato; H Yoshimura; K Wada; H Hashimoto; M Takada; K Tanaka; T Nakatani; M Shibakawa Journal: Clin Pharmacol Ther Date: 2000-12 Impact factor: 6.875
Authors: M D Hale; A J Nicholls; R E Bullingham; R Hené; A Hoitsma; J P Squifflet; W Weimar; Y Vanrenterghem; F J Van de Woude; G A Verpooten Journal: Clin Pharmacol Ther Date: 1998-12 Impact factor: 6.875
Authors: David W Mudge; Bronwyn Atcheson; Paul J Taylor; Joanna M Sturtevant; Carmel M Hawley; Scott B Campbell; Nicole M Isbel; David L Nicol; Peter I Pillans; David W Johnson Journal: Transplantation Date: 2004-01-27 Impact factor: 4.939
Authors: Sijie Zheng; Daniel W Coyne; Heidi Joist; Rebecca Schuessler; Ambyr Godboldo-Brooks; Patrick Ercole; Daniel C Brennan Journal: Transpl Int Date: 2008-12-09 Impact factor: 3.782