AIMS: To determine infant exposure to 6-thioguanine and 6-methylmercaptopurine nucleotides (6-TGN and 6-MMPN, respectively) during maternal use of azathioprine in breastfeeding. METHODS: Mother-infant pairs provided blood for determination of 6-TGN and 6-MMPN concentrations, and TPMT genotype. RESULTS: Four women taking azathioprine 1.2-2.1 mg kg(-1) day(-1) and their infants were studied. All had the wild-type TPMT genotype. Maternal 6-TGN and 6-MMPN concentrations ranged from 234 to 291 and 284 to 1178 pmol per 8 x 10(8) red blood cells, respectively, and were consistent with those associated with improved therapeutic outcomes. Neither 6-TGN nor 6-MMPN was detected in any of the infants, despite a sensitive assay. CONCLUSIONS: The data suggest that azathioprine may be 'safe' during breastfeeding in patients with the wild-type TPMT genotype ( approximately 90% of caucasian patients) taking 'normal' doses.
AIMS: To determine infant exposure to 6-thioguanine and 6-methylmercaptopurine nucleotides (6-TGN and 6-MMPN, respectively) during maternal use of azathioprine in breastfeeding. METHODS: Mother-infant pairs provided blood for determination of 6-TGN and 6-MMPN concentrations, and TPMT genotype. RESULTS: Four women taking azathioprine 1.2-2.1 mg kg(-1) day(-1) and their infants were studied. All had the wild-type TPMT genotype. Maternal 6-TGN and 6-MMPN concentrations ranged from 234 to 291 and 284 to 1178 pmol per 8 x 10(8) red blood cells, respectively, and were consistent with those associated with improved therapeutic outcomes. Neither 6-TGN nor 6-MMPN was detected in any of the infants, despite a sensitive assay. CONCLUSIONS: The data suggest that azathioprine may be 'safe' during breastfeeding in patients with the wild-type TPMT genotype ( approximately 90% of caucasian patients) taking 'normal' doses.
Authors: R B Gearry; M L Barclay; R L Roberts; J Harraway; M Zhang; L S Pike; P M George; C M Florkowski Journal: Intern Med J Date: 2005-10 Impact factor: 2.048
Authors: M C Dubinsky; S Lamothe; H Y Yang; S R Targan; D Sinnett; Y Théorêt; E G Seidman Journal: Gastroenterology Date: 2000-04 Impact factor: 22.682
Authors: Christiaan Sies; Christopher Florkowski; Peter George; Richard Gearry; Murray Barclay; James Harraway; Linda Pike; Trevor Walmsley Journal: N Z Med J Date: 2005-02-25
Authors: Luc J J Derijks; Lennard P L Gilissen; Leopold G J B Engels; Laurens P Bos; Paul J Bus; Joseph J H M Lohman; Wouter L Curvers; Sander J H Van Deventer; Daniel W Hommes; Piet M Hooymans Journal: Ther Drug Monit Date: 2004-06 Impact factor: 3.681