PURPOSE: The purpose of this study is to assess the ability of potential clinical predictors and inflammatory markers to predict intensive care unit (ICU) readmission during the same hospitalization. MATERIALS AND METHODS: A nested case-control study utilized prospectively collected de-identified data of a 22-bed multidisciplinary ICU in a university hospital. RESULTS: There were 1,405 consecutive ICU admissions in 2004, and of these, 18 were regarded as ICU readmissions (1.3%). The destination and timing of ICU discharge, the Sequential Organ Failure Assessment scores, white cell counts, and fibrinogen concentrations at discharge were not associated with ICU readmission. C-reactive protein (CRP) concentration within 24 hours before ICU discharge was associated with ICU readmission (mean CRP concentrations of cases vs controls, 177.8 vs 56.5 mg/L, respectively; P < .0001). The results remained unchanged after adjustment with the propensity scores. The area under the receiver operating characteristic curve for the CRP concentrations to predict ICU readmission was 0.884 (95% confidence interval, 0.765-0.999; P < .0001). Patients readmitted to the ICU had a higher predicted mortality in their second ICU admission (34.9% vs 26.1%; P < .01) and a longer total hospital stay (33.3 vs 20.3 days; P < .003) than patients without ICU readmission. CONCLUSIONS: A high CRP concentration within 24 hours before ICU discharge is associated with a higher risk of readmission to the ICU.
PURPOSE: The purpose of this study is to assess the ability of potential clinical predictors and inflammatory markers to predict intensive care unit (ICU) readmission during the same hospitalization. MATERIALS AND METHODS: A nested case-control study utilized prospectively collected de-identified data of a 22-bed multidisciplinary ICU in a university hospital. RESULTS: There were 1,405 consecutive ICU admissions in 2004, and of these, 18 were regarded as ICU readmissions (1.3%). The destination and timing of ICU discharge, the Sequential Organ Failure Assessment scores, white cell counts, and fibrinogen concentrations at discharge were not associated with ICU readmission. C-reactive protein (CRP) concentration within 24 hours before ICU discharge was associated with ICU readmission (mean CRP concentrations of cases vs controls, 177.8 vs 56.5 mg/L, respectively; P < .0001). The results remained unchanged after adjustment with the propensity scores. The area under the receiver operating characteristic curve for the CRP concentrations to predict ICU readmission was 0.884 (95% confidence interval, 0.765-0.999; P < .0001). Patients readmitted to the ICU had a higher predicted mortality in their second ICU admission (34.9% vs 26.1%; P < .01) and a longer total hospital stay (33.3 vs 20.3 days; P < .003) than patients without ICU readmission. CONCLUSIONS: A high CRP concentration within 24 hours before ICU discharge is associated with a higher risk of readmission to the ICU.
Authors: Samir M Fakhry; Stuart Leon; Chris Derderian; Hasan Al-Harakeh; Pamela L Ferguson Journal: J Trauma Acute Care Surg Date: 2013-06 Impact factor: 3.313
Authors: Joana Silvestre; Luis Coelho; João Gonçalves Pereira; Vitor Mendes; Camila Tapadinhas; Pedro Póvoa Journal: Rev Bras Ter Intensiva Date: 2019-01-10
Authors: Otavio T Ranzani; Fernando Godinho Zampieri; Daniel Neves Forte; Luciano Cesar Pontes Azevedo; Marcelo Park Journal: PLoS One Date: 2013-03-12 Impact factor: 3.240
Authors: Ji Eun Park; Kyung Soo Chung; Joo Han Song; Song Yee Kim; Eun Young Kim; Ji Ye Jung; Young Ae Kang; Moo Suk Park; Young Sam Kim; Joon Chang; Ah Young Leem Journal: J Clin Med Date: 2018-10-08 Impact factor: 4.241