Literature DB >> 16989535

Awajanomycin, a Cytotoxic gamma-lactone-delta-lactam metabolite from marine-derived Acremonium sp. AWA16-1.

Jae-Hyuk Jang1, Kaneo Kanoh, Kyoko Adachi, Yoshikazu Shizuri.   

Abstract

The new fungal metabolite awajanomycin (1), which has gamma-lactone-delta-lactam rings, was isolated from the marine-derived fungus Acremonium sp. AWA16-1, which had been collected from sea mud off Awajishima Island in Japan. The structure of 1 was elucidated by spectroscopic analysis and chemical methods. Awajanomycin (1) and its derivative (2) inhibited the growth of A549 cells with IC(50) values of 27.5 and 46.4 microg/mL, respectively.

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Year:  2006        PMID： 16989535     DOI： 10.1021/np060170a

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  3 in total

1.  Antineoplastic agents. 570. Isolation and structure elucidation of bacillistatins 1 and 2 from a marine Bacillus silvestris.

Authors:  George R Pettit; John C Knight; Delbert L Herald; Robin K Pettit; Fiona Hogan; Venugopal J R V Mukku; John S Hamblin; Michael J Dodson; Jean-Charles Chapuis
Journal:  J Nat Prod       Date:  2009-03-27       Impact factor: 4.050

2.  Visible-light photoredox-catalyzed umpolung carboxylation of carbonyl compounds with CO2.

Authors:  Guang-Mei Cao; Xin-Long Hu; Li-Li Liao; Si-Shun Yan; Lei Song; Jason J Chruma; Li Gong; Da-Gang Yu
Journal:  Nat Commun       Date:  2021-06-03       Impact factor: 14.919

Review 3.  Fungal Lactamases: Their Occurrence and Function.

Authors:  Minglu Gao; Anthony E Glenn; Alex A Blacutt; Scott E Gold
Journal:  Front Microbiol       Date:  2017-09-19       Impact factor: 5.640
  3 in total

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