Literature DB >> 16988280

Application of mutated Clostridium difficile toxin A for determination of glucosyltransferase-dependent effects.

Matthias Teichert1, Helma Tatge, Janett Schoentaube, Ingo Just, Ralf Gerhard.   

Abstract

Mutation of tryptophan-101 in Clostridium difficile toxin A, a 308-kDa glucosyltransferase, resulted in a 50-fold-reduced cytopathic activity in cell culture experiments. The mutant toxin A was characterized and applied to distinguish between glucosyltransferase-dependent and -independent effects with respect to RhoB up-regulation as a cellular stress response.

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Year:  2006        PMID： 16988280      PMCID： PMC1594915          DOI： 10.1128/IAI.00545-06

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  20 in total

1.  Differential effects of Rho GTPases on axonal and dendritic development in hippocampal neurones.

Authors:  G Ahnert-Hilger; M Höltje; G Grosse; G Pickert; C Mucke; B Nixdorf-Bergweiler; P Boquet; F Hofmann; I Just
Journal:  J Neurochem       Date:  2004-07       Impact factor: 5.372

2.  Cellular stability of Rho-GTPases glucosylated by Clostridium difficile toxin B.

Authors:  Harald Genth; Johannes Huelsenbeck; Birgit Hartmann; Fred Hofmann; Ingo Just; Ralf Gerhard
Journal:  FEBS Lett       Date:  2006-05-22       Impact factor: 4.124

3.  Involvement of a conserved tryptophan residue in the UDP-glucose binding of large clostridial cytotoxin glycosyltransferases.

Authors:  C Busch; F Hofmann; R Gerhard; K Aktories
Journal:  J Biol Chem       Date:  2000-05-05       Impact factor: 5.157

4.  Leptin mediates Clostridium difficile toxin A-induced enteritis in mice.

Authors:  Andreas Mykoniatis; Pauline M Anton; Michael Wlk; Chi Chung Wang; Linda Ungsunan; Susann Blüher; Maria Venihaki; Simos Simeonidis; Jeff Zacks; Dezheng Zhao; Stavros Sougioultzis; Katia Karalis; Christos Mantzoros; Charalabos Pothoulakis
Journal:  Gastroenterology       Date:  2003-03       Impact factor: 22.682

5.  Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves Rho family small GTPases.

Authors:  Dezheng Zhao; Sabina Kuhnt-Moore; Huiyan Zeng; Amy Pan; Jack S Wu; Simos Simeonidis; Mary P Moyer; Charalabos Pothoulakis
Journal:  Biochem J       Date:  2002-12-01       Impact factor: 3.857

6.  Clostridium difficile toxin B activates dual caspase-dependent and caspase-independent apoptosis in intoxicated cells.

Authors:  Maen Qa'Dan; Matthew Ramsey; Jeremy Daniel; Lea M Spyres; Barbara Safiejko-Mroczka; William Ortiz-Leduc; Jimmy D Ballard
Journal:  Cell Microbiol       Date:  2002-07       Impact factor: 3.715

7.  Fluorescent analogs of UDP-glucose and their use in characterizing substrate binding by toxin A from Clostridium difficile.

Authors:  Sudeep Bhattacharyya; Amy Kerzmann; Andrew L Feig
Journal:  Eur J Biochem       Date:  2002-07

8.  Expression of recombinant Clostridium difficile toxin A using the Bacillus megaterium system.

Authors:  Silke Burger; Helma Tatge; Fred Hofmann; Harald Genth; Ingo Just; Ralf Gerhard
Journal:  Biochem Biophys Res Commun       Date:  2003-08-01       Impact factor: 3.575

9.  Clostridium difficile toxin B is an inflammatory enterotoxin in human intestine.

Authors:  Tor C Savidge; Wei-Hua Pan; Paul Newman; Michael O'brien; Pauline M Anton; Charalabos Pothoulakis
Journal:  Gastroenterology       Date:  2003-08       Impact factor: 22.682

10.  Corticotropin-releasing hormone (CRH) requirement in Clostridium difficile toxin A-mediated intestinal inflammation.

Authors:  Pauline M Anton; Jerome Gay; Andreas Mykoniatis; Amy Pan; Michael O'Brien; Daniel Brown; Katia Karalis; Charalabos Pothoulakis
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-24       Impact factor: 11.205
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  22 in total

1.  Glucosylation Drives the Innate Inflammatory Response to Clostridium difficile Toxin A.

Authors:  Carrie A Cowardin; Brianna M Jackman; Zannatun Noor; Stacey L Burgess; Andrew L Feig; William A Petri
Journal:  Infect Immun       Date:  2016-07-21       Impact factor: 3.441

2.  The Type IV Secretion System Effector Protein CirA Stimulates the GTPase Activity of RhoA and Is Required for Virulence in a Mouse Model of Coxiella burnetii Infection.

Authors:  Mary M Weber; Robert Faris; Erin J van Schaik; Juanita Thrasher McLachlan; William U Wright; Andres Tellez; Victor A Roman; Kristina Rowin; Elizabeth Di Russo Case; Zhao-Qing Luo; James E Samuel
Journal:  Infect Immun       Date:  2016-08-19       Impact factor: 3.441

3.  Down-regulation of interleukin-16 in human mast cells HMC-1 by Clostridium difficile toxins A and B.

Authors:  Ralf Gerhard; Swenja Queisser; Helma Tatge; Gesa Meyer; Oliver Dittrich-Breiholz; Michael Kracht; Hanping Feng; Ingo Just
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2011-01-26       Impact factor: 3.000

4.  Caspase activation as a versatile assay platform for detection of cytotoxic bacterial toxins.

Authors:  Angela M Payne; Julie Zorman; Melanie Horton; Sheri Dubey; Jan ter Meulen; Kalpit A Vora
Journal:  J Clin Microbiol       Date:  2013-07-03       Impact factor: 5.948

5.  Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.

Authors:  Joseph W Alvin; D Borden Lacy
Journal:  J Struct Biol       Date:  2017-04-19       Impact factor: 2.867

6.  Crystal structure of Clostridium difficile toxin A.

Authors:  Nicole M Chumbler; Stacey A Rutherford; Zhifen Zhang; Melissa A Farrow; John P Lisher; Erik Farquhar; David P Giedroc; Benjamin W Spiller; Roman A Melnyk; D Borden Lacy
Journal:  Nat Microbiol       Date:  2016-01-11       Impact factor: 17.745

7.  Recombinant Mucin-Type Fusion Proteins with a Galα1,3Gal Substitution as Clostridium difficile Toxin A Inhibitors.

Authors:  Reeja Maria Cherian; Chunsheng Jin; Jining Liu; Niclas G Karlsson; Jan Holgersson
Journal:  Infect Immun       Date:  2016-09-19       Impact factor: 3.441

8.  Essential role of the glucosyltransferase activity in Clostridium difficile toxin-induced secretion of TNF-alpha by macrophages.

Authors:  Xingmin Sun; Xiangyun He; Saul Tzipori; Ralf Gerhard; Hanping Feng
Journal:  Microb Pathog       Date:  2009-03-24       Impact factor: 3.738

Review 9.  Pathogenic effects of glucosyltransferase from Clostridium difficile toxins.

Authors:  Yongrong Zhang; Hanping Feng
Journal:  Pathog Dis       Date:  2016-04-04       Impact factor: 3.166

10.  Truncation in the tcdC region of the Clostridium difficile PathLoc of clinical isolates does not predict increased biological activity of Toxin B or Toxin A.

Authors:  Ruth Murray; Dave Boyd; Paul N Levett; Michael R Mulvey; Michelle J Alfa
Journal:  BMC Infect Dis       Date:  2009-06-28       Impact factor: 3.090
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