Literature DB >> 27044305

Pathogenic effects of glucosyltransferase from Clostridium difficile toxins.

Yongrong Zhang1, Hanping Feng2.   

Abstract

The glucosyltransferase domain ofClostridium difficiletoxins modifies guanine nucleotide-binding proteins of Rho family. It is the major virulent domain of the holotoxins. Various pathogenic effects ofC. difficiletoxins in response to Rho glucosylation have been investigated including cytoskeleton damage, cell death and inflammation. The most recent studies have revealed some significant characteristics of the holotoxins that are independent of glucosylating activity. These findings arouse discussion about the role of glucosyltransferase activity in toxin pathogenesis and open up new insights for toxin mechanism study. In this review, we summarize the pathogenic effects of glucosyltransferase domain of the toxins in the past years. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  Clostridium difficile; glucosyltransferase; pathogenesis; toxins

Mesh：

Substances：

Year:  2016        PMID： 27044305      PMCID： PMC5985493          DOI： 10.1093/femspd/ftw024

Source DB:  PubMed          Journal:  Pathog Dis        ISSN： 2049-632X            Impact factor:   3.166


  74 in total

1.  Evidence for a modular structure of the homologous repetitive C-terminal carbohydrate-binding sites of Clostridium difficile toxins and Streptococcus mutans glucosyltransferases.

Authors:  C von Eichel-Streiber; M Sauerborn; H K Kuramitsu
Journal:  J Bacteriol       Date:  1992-10       Impact factor: 3.490

2.  Structural determinants for membrane insertion, pore formation and translocation of Clostridium difficile toxin B.

Authors:  Selda Genisyuerek; Panagiotis Papatheodorou; Gregor Guttenberg; Rolf Schubert; Roland Benz; Klaus Aktories
Journal:  Mol Microbiol       Date:  2011-01-28       Impact factor: 3.501

3.  Repetitive domain of Clostridium difficile toxin B exhibits cytotoxic effects on human intestinal epithelial cells and decreases epithelial barrier function.

Authors:  Mateja Zemljic; Maja Rupnik; Melania Scarpa; Gregor Anderluh; Gorgio Palù; Ignazio Castagliuolo
Journal:  Anaerobe       Date:  2010-07-08       Impact factor: 3.331

4.  Clostridium difficile toxin B activates the EGF receptor and the ERK/MAP kinase pathway in human colonocytes.

Authors:  Xi Na; Dezheng Zhao; Hon Wai Koon; Ho Kim; Johanna Husmark; Mary P Moyer; Charalabos Pothoulakis; J Thomas LaMont
Journal:  Gastroenterology       Date:  2005-04       Impact factor: 22.682

5.  Clostridium difficile toxin B activates dual caspase-dependent and caspase-independent apoptosis in intoxicated cells.

Authors:  Maen Qa'Dan; Matthew Ramsey; Jeremy Daniel; Lea M Spyres; Barbara Safiejko-Mroczka; William Ortiz-Leduc; Jimmy D Ballard
Journal:  Cell Microbiol       Date:  2002-07       Impact factor: 3.715

6.  Human alpha-defensins inhibit Clostridium difficile toxin B.

Authors:  Torsten Giesemann; Gregor Guttenberg; Klaus Aktories
Journal:  Gastroenterology       Date:  2008-03-10       Impact factor: 22.682

7.  Fidaxomicin inhibits Clostridium difficile toxin A-mediated enteritis in the mouse ileum.

Authors:  Hon Wai Koon; Samantha Ho; Tressia C Hing; Michelle Cheng; Xinhua Chen; Yoshi Ichikawa; Ciarán P Kelly; Charalabos Pothoulakis
Journal:  Antimicrob Agents Chemother       Date:  2014-06-02       Impact factor: 5.191

8.  The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins.

Authors:  I Just; M Wilm; J Selzer; G Rex; C von Eichel-Streiber; M Mann; K Aktories
Journal:  J Biol Chem       Date:  1995-06-09       Impact factor: 5.157

9.  High temporal resolution of glucosyltransferase dependent and independent effects of Clostridium difficile toxins across multiple cell types.

Authors:  Kevin M D'Auria; Meghan J Bloom; Yesenia Reyes; Mary C Gray; Edward J van Opstal; Jason A Papin; Erik L Hewlett
Journal:  BMC Microbiol       Date:  2015-02-04       Impact factor: 3.605

10.  Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections.

Authors:  Glen P Carter; Anjana Chakravorty; Tu Anh Pham Nguyen; Steven Mileto; Fernanda Schreiber; Lucy Li; Pauline Howarth; Simon Clare; Bliss Cunningham; Susan P Sambol; Adam Cheknis; Iris Figueroa; Stuart Johnson; Dale Gerding; Julian I Rood; Gordon Dougan; Trevor D Lawley; Dena Lyras
Journal:  MBio       Date:  2015-06-02       Impact factor: 7.867
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  2 in total

1.  Phosphorylation and functionality of CdtR in Clostridium difficile.

Authors:  T W Bilverstone; N P Minton; S A Kuehne
Journal:  Anaerobe       Date:  2019-07-16       Impact factor: 3.331

2.  The development of live biotherapeutics against Clostridioides difficile infection towards reconstituting gut microbiota.

Authors:  Yongrong Zhang; Ashley Saint Fleur; Hanping Feng
Journal:  Gut Microbes       Date:  2022 Jan-Dec
  2 in total

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