Literature DB >> 16982076

Quasispecies and recombination.

Martin Nilsson Jacobi1, Mats Nordahl.   

Abstract

Recombination is introduced into Eigen's theory of quasispecies evolution. Comparing numerical simulations of the rate equations in the non-recombining and recombining cases show that recombination has a strong effect on the error threshold and, for a wide range of mutation rates, gives rise to two stable fixed points in the dynamics. This bi-stability results in the existence of two error thresholds. However, we prove that, for low mutation rates the bi-stability breaks down and the unique equilibrium distribution is concentrated around the sequence with highest fitness.

Mesh:

Year:  2006        PMID: 16982076     DOI: 10.1016/j.tpb.2006.08.002

Source DB:  PubMed          Journal:  Theor Popul Biol        ISSN: 0040-5809            Impact factor:   1.570


  5 in total

Review 1.  Viral quasispecies evolution.

Authors:  Esteban Domingo; Julie Sheldon; Celia Perales
Journal:  Microbiol Mol Biol Rev       Date:  2012-06       Impact factor: 11.056

2.  Bistability in two-locus models with selection, mutation, and recombination.

Authors:  Su-Chan Park; Joachim Krug
Journal:  J Math Biol       Date:  2010-07-09       Impact factor: 2.259

3.  A framework for inferring fitness landscapes of patient-derived viruses using quasispecies theory.

Authors:  David Seifert; Francesca Di Giallonardo; Karin J Metzner; Huldrych F Günthard; Niko Beerenwinkel
Journal:  Genetics       Date:  2014-11-17       Impact factor: 4.562

Review 4.  Quasispecies and virus.

Authors:  Esteban Domingo; Celia Perales
Journal:  Eur Biophys J       Date:  2018-02-03       Impact factor: 1.733

5.  Quasispecies theory for horizontal gene transfer and recombination.

Authors:  Enrique Muñoz; Jeong-Man Park; Michael W Deem
Journal:  Phys Rev E Stat Nonlin Soft Matter Phys       Date:  2008-12-23
  5 in total

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