| Literature DB >> 16982076 |
Martin Nilsson Jacobi1, Mats Nordahl.
Abstract
Recombination is introduced into Eigen's theory of quasispecies evolution. Comparing numerical simulations of the rate equations in the non-recombining and recombining cases show that recombination has a strong effect on the error threshold and, for a wide range of mutation rates, gives rise to two stable fixed points in the dynamics. This bi-stability results in the existence of two error thresholds. However, we prove that, for low mutation rates the bi-stability breaks down and the unique equilibrium distribution is concentrated around the sequence with highest fitness.Mesh:
Year: 2006 PMID: 16982076 DOI: 10.1016/j.tpb.2006.08.002
Source DB: PubMed Journal: Theor Popul Biol ISSN: 0040-5809 Impact factor: 1.570