OBJECTIVE: To determine the effect of nephroureterectomy (NU) on the glomerular filtration rate (GFR), and to determine whether the estimated GFR after NU is influenced by age and other factors associated with renal impairment. PATIENTS AND METHODS: We retrospectively identified 131 patients who had had a NU at either of two UK institutions. Their serum creatinine levels were recorded before and after NU, along with comorbidity data, and from this their GFR before and after NU was estimated using the Modification of Diet in Renal Disease Study Group equation. RESULTS: At a median follow-up of 5 years there was an 18% deterioration in estimated GFR in the 131 patients. The percentage deterioration in estimated GFR was greater in those aged >or= 70 years than in those aged <70 years (20% vs 15% deterioration). Those with more risk factors for renal impairment had a greater percentage deterioration in estimated GFR than those with no such risk factors. CONCLUSIONS: This study shows that NU has a profound effect on future estimated GFR, an effect that is further compounded in those with risk factors for renal impairment. This study therefore provides both the patient and the urologist with an idea of potential future renal function after NU and contributes greatly to preoperative counselling.
OBJECTIVE: To determine the effect of nephroureterectomy (NU) on the glomerular filtration rate (GFR), and to determine whether the estimated GFR after NU is influenced by age and other factors associated with renal impairment. PATIENTS AND METHODS: We retrospectively identified 131 patients who had had a NU at either of two UK institutions. Their serum creatinine levels were recorded before and after NU, along with comorbidity data, and from this their GFR before and after NU was estimated using the Modification of Diet in Renal Disease Study Group equation. RESULTS: At a median follow-up of 5 years there was an 18% deterioration in estimated GFR in the 131 patients. The percentage deterioration in estimated GFR was greater in those aged >or= 70 years than in those aged <70 years (20% vs 15% deterioration). Those with more risk factors for renal impairment had a greater percentage deterioration in estimated GFR than those with no such risk factors. CONCLUSIONS: This study shows that NU has a profound effect on future estimated GFR, an effect that is further compounded in those with risk factors for renal impairment. This study therefore provides both the patient and the urologist with an idea of potential future renal function after NU and contributes greatly to preoperative counselling.
Authors: Matthew G Kaag; Rebecca L O'Malley; Padraic O'Malley; Guilherme Godoy; Mang Chen; Marc C Smaldone; Ronald L Hrebinko; Jay D Raman; Bernard Bochner; Guido Dalbagni; Michael D Stifelman; Samir S Taneja; William C Huang Journal: Eur Urol Date: 2010-06-25 Impact factor: 20.096
Authors: Alessandro Tafuri; Michele Marchioni; Clara Cerrato; Andrea Mari; Riccardo Tellini; Katia Odorizzi; Alessandro Veccia; Daniele Amparore; Aliasger Shakir; Umberto Carbonara; Andrea Panunzio; Federica Trovato; Michele Catellani; Letizia M I Janello; Lorenzo Bianchi; Giacomo Novara; Fabrizio Dal Moro; Riccardo Schiavina; Elisa De Lorenzis; Paolo Parma; Sebastiano Cimino; Ottavio De Cobelli; Francesco Maiorino; Pierluigi Bove; Fabio Crocerossa; Francesco Cantiello; David D'Andrea; Federica Di Cosmo; Francesco Porpiglia; Pasquale Ditonno; Emanuele Montanari; Francesco Soria; Paolo Gontero; Giovanni Liguori; Carlo Trombetta; Guglielmo Mantica; Marco Borghesi; Carlo Terrone; Francesco Del Giudice; Alessandro Sciarra; Andrea Galosi; Marco Moschini; Shahrokh F Shariat; Marta Di Nicola; Andrea Minervini; Matteo Ferro; Maria Angela Cerruto; Luigi Schips; Vincenzo Pagliarulo; Alessandro Antonelli Journal: World J Urol Date: 2022-10-06 Impact factor: 3.661
Authors: Esmee Cm Kooijmans; Arend Bökenkamp; Nic S Tjahjadi; Jesse M Tettero; Eline van Dulmen-den Broeder; Helena Jh van der Pal; Margreet A Veening Journal: Cochrane Database Syst Rev Date: 2019-03-11