Gail Ishiyama1, Ivan A López, Akira Ishiyama. 1. Department of Neurology, Division of Head and Neck Surgery, David Geffen School of Medicine at the University of California, Los Angeles 90095, USA. ishiyama@ucla.edu
Abstract
PURPOSE OF REVIEW: Review of the role of aquaporins in inner ear homeostasis and potential role in the pathogenesis of Meniere's disease. RECENT FINDINGS: Recent findings include the immunolocalization of aquaporins in the inner ear of mouse, rat, and human to cell types that are likely to undergo high ionic perturbances (e.g. potassium flux) and to putative areas of endolymph resorption or cycling. SUMMARY: The expression of aquaporins and related proteins in the human cochlea and vestibular periphery resembles the distribution found in animal models, suggesting a critical role of aquaporins in inner ear water homeostasis and their potential role in the pathogenesis of Meniere's disease.
PURPOSE OF REVIEW: Review of the role of aquaporins in inner ear homeostasis and potential role in the pathogenesis of Meniere's disease. RECENT FINDINGS: Recent findings include the immunolocalization of aquaporins in the inner ear of mouse, rat, and human to cell types that are likely to undergo high ionic perturbances (e.g. potassium flux) and to putative areas of endolymph resorption or cycling. SUMMARY: The expression of aquaporins and related proteins in the human cochlea and vestibular periphery resembles the distribution found in animal models, suggesting a critical role of aquaporins in inner ear water homeostasis and their potential role in the pathogenesis of Meniere's disease.
Authors: Andrew A McCall; Gail P Ishiyama; Ivan A Lopez; Sunita Bhuta; Steven Vetter; Akira Ishiyama Journal: BMC Ear Nose Throat Disord Date: 2009-06-03
Authors: Ivan A Lopez; Mark I Rosenblatt; Charles Kim; Gary C Galbraith; Sherri M Jones; Liyo Kao; Debra Newman; Weixin Liu; Stacey Yeh; Alexander Pushkin; Natalia Abuladze; Ira Kurtz Journal: J Biol Chem Date: 2009-07-08 Impact factor: 5.157