Mohamed Hamid1, Dennis Trune. 1. The Cleveland Hearing & Balance Center, Cleveland, Ohio 44122, USA. hamidma@ClevelandHearingBalance.com
Abstract
PURPOSE OF REVIEW: Office-based intratympanic inner ear steroid perfusion (ITPs) treatment for Ménière's disease, autoimmune inner ear disease, and sudden sensorineural hearing loss has been expanding over the past 10-15 years, yet remains controversial. The purpose of this review is to examine the current literature of basic science and human studies of ITPs treatment. RECENT FINDINGS: Animal studies exist regarding the delivery, distribution, biochemical, and microbiological changes in the inner ear post ITPs. However, few clinical studies exist on ITPs treatment in sudden sensorineural hearing loss and even less in treating Ménière's disease. There are no consistent studies regarding drug delivery methods, type, and concentration of steroids. Moreover, there are no studies comparing ITPs results to the natural history of Ménière's disease. SUMMARY: ITPs has impacted otology and neurotology practice due to increased utilization. A sound understanding of the basic science and clinical studies is needed to establish long-term efficacy of ITPs in controlling hearing loss in Ménière's disease by comparison to its natural history, as well as, potential application to other disorders.
PURPOSE OF REVIEW: Office-based intratympanic inner ear steroid perfusion (ITPs) treatment for Ménière's disease, autoimmune inner ear disease, and sudden sensorineural hearing loss has been expanding over the past 10-15 years, yet remains controversial. The purpose of this review is to examine the current literature of basic science and human studies of ITPs treatment. RECENT FINDINGS: Animal studies exist regarding the delivery, distribution, biochemical, and microbiological changes in the inner ear post ITPs. However, few clinical studies exist on ITPs treatment in sudden sensorineural hearing loss and even less in treating Ménière's disease. There are no consistent studies regarding drug delivery methods, type, and concentration of steroids. Moreover, there are no studies comparing ITPs results to the natural history of Ménière's disease. SUMMARY:ITPs has impacted otology and neurotology practice due to increased utilization. A sound understanding of the basic science and clinical studies is needed to establish long-term efficacy of ITPs in controlling hearing loss in Ménière's disease by comparison to its natural history, as well as, potential application to other disorders.
Authors: Richard D Kopke; Ronald L Jackson; John K M Coleman; Jianzhong Liu; Eric C Bielefeld; Ben J Balough Journal: Hear Res Date: 2006-12-20 Impact factor: 3.208
Authors: C Martín González; F M González; A Trinidad; A Ibáñez; M Pinilla; A Martínez Ruiz-Coello; A Rodríguez Valiente; C López-Cortijo Journal: Eur Arch Otorhinolaryngol Date: 2010-05-08 Impact factor: 2.503
Authors: Young Ho Kim; Kyung Tae Park; Byung Yoon Choi; Min Hyun Park; Jun Ho Lee; Seung-Ha Oh; Sun O Chang Journal: Eur Arch Otorhinolaryngol Date: 2011-12-08 Impact factor: 2.503
Authors: Debashree Mukherjea; Sarvesh Jajoo; Tejbeer Kaur; Kelly E Sheehan; Vickram Ramkumar; Leonard P Rybak Journal: Antioxid Redox Signal Date: 2010-09-01 Impact factor: 8.401
Authors: Jong Bin Lee; Seong Jun Choi; Keehyun Park; Hun Yi Park; Oak-Sung Choo; Yun-Hoon Choung Journal: Eur Arch Otorhinolaryngol Date: 2011-01-08 Impact factor: 2.503