| Literature DB >> 16973862 |
Edward C Holmes1, David J Lipman, Dmitriy Zamarin, Jonathan W Yewdell.
Abstract
Obenauer et al. (Research Articles, 17 March 2006, p. 1576) reported that the influenza A virus PB1-F2 gene is evolving under strong positive selection, as documented by an extremely high ratio of the number of nonsynonymous nucleotide substitutions to the number of synonymous substitutions (dN/dS). However, we show that this observation is likely to be an artifact related to the location of PB1-F2 in the +1 reading frame of the PB1 gene.Entities:
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Year: 2006 PMID: 16973862 DOI: 10.1126/science.1131729
Source DB: PubMed Journal: Science ISSN: 0036-8075 Impact factor: 47.728