Literature DB >> 16970134

Is digoxin a drug of the past?

Mohammad Hassan Pervaiz1, Michael G Dickinson, Mohamad Yamani.   

Abstract

Digoxin has been the cornerstone of the treatment of heart failure for more than 2 centuries. Now that newer therapies have been introduced that reduce the mortality rate in heart failure and recent trials have failed to prove the same for digoxin, its use has significantly decreased. But a careful review of the multiple pharmacologic actions of digoxin and closer analysis of the results of recent trials suggest that digoxin may in fact continue to be an effective treatment for heart failure.

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Year:  2006        PMID： 16970134     DOI： 10.3949/ccjm.73.9.821

Source DB:  PubMed          Journal:  Cleve Clin J Med        ISSN： 0891-1150            Impact factor:   2.321


  10 in total

1.  Characterization of the mechanisms of the increase in PPARδ expression induced by digoxin in the heart using the H9c2 cell line.

Authors:  Zhih-Cherng Chen; Bu-Chin Yu; Li-Jen Chen; Kai-Chun Cheng; Hung Jung Lin; Juei-Tang Cheng
Journal:  Br J Pharmacol       Date:  2011-05       Impact factor: 8.739

2.  Risk of digoxin intoxication in heart failure patients exposed to digoxin-diuretic interactions: a population-based study.

Authors:  Meng-Ting Wang; Chen-Yi Su; Agnes L F Chan; Pei-Wen Lian; Hsin-Bang Leu; Yu-Juei Hsu
Journal:  Br J Clin Pharmacol       Date:  2010-08       Impact factor: 4.335

3.  The cardiotonic steroid hormone marinobufagenin induces renal fibrosis: implication of epithelial-to-mesenchymal transition.

Authors:  Larisa V Fedorova; Vanamala Raju; Nasser El-Okdi; Amjad Shidyak; David J Kennedy; Sandeep Vetteth; David R Giovannucci; Alexei Y Bagrov; Olga V Fedorova; Joseph I Shapiro; Deepak Malhotra
Journal:  Am J Physiol Renal Physiol       Date:  2009-01-28

4.  Emergency department visits and hospitalizations for digoxin toxicity: United States, 2005 to 2010.

Authors:  Isaac See; Nadine Shehab; Scott R Kegler; S Raja Laskar; Daniel S Budnitz
Journal:  Circ Heart Fail       Date:  2013-12-03       Impact factor: 8.790

5.  A New Method for Individualized Digoxin Dosing in Elderly Patients.

Authors:  Ana Martin-Suarez; David García González; Juan F Macías Núñez; Ramón Ardanuy Albajar; M Victoria Calvo Hernández
Journal:  Drugs Aging       Date:  2016-04       Impact factor: 3.923

6.  The assessment of renal function in relation to the use of drugs in elderly in nursing homes; a cohort study.

Authors:  Sara Modig; Christina Lannering; Carl Johan Ostgren; Sigvard Mölstad; Patrik Midlöv
Journal:  BMC Geriatr       Date:  2011-01-11       Impact factor: 3.921

7.  Digoxin inhibits PDGF-BB-induced VSMC proliferation and migration through an increase in ILK signaling and attenuates neointima formation following carotid injury.

Authors:  Gaoliang Yan; Qingjie Wang; Shengda Hu; Dong Wang; Yong Qiao; Genshan Ma; Chengchun Tang; Yuchun Gu
Journal:  Int J Mol Med       Date:  2015-08-21       Impact factor: 4.101

8.  Intermittent low-dose digoxin may be effective and safe in patients with chronic heart failure undergoing maintenance hemodialysis.

Authors:  Xiaozhao Li; Xiang Ao; Qiong Liu; Jinghua Yang; Weisheng Peng; Rong Tang; Yong Zhong; Ting Meng; Lu Gan; Qiaoling Zhou
Journal:  Exp Ther Med       Date:  2014-10-09       Impact factor: 2.447

9.  Glomerular filtration rate estimation using the Cockcroft-Gault and modification of diet in renal disease formulas for digoxin dose adjustment in patients with heart failure.

Authors:  Marta Vazquez-Hernandez; Lorena Bouzas; J Carlos Tutor
Journal:  Ups J Med Sci       Date:  2009       Impact factor: 2.384

10.  Efficiency of individual dosage of digoxin with calculated concentration.

Authors:  Li Zhao; Peng Yang; Pengmei Li; Xiaoxing Wang; Wangjun Qin; Xianglin Zhang
Journal:  Clin Interv Aging       Date:  2014-07-22       Impact factor: 4.458
  10 in total

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