Literature DB >> 16967204

Effect of improved zinc status on T helper cell activation and TH1/TH2 ratio in healthy elderly individuals.

Laura Kahmann1, Peter Uciechowski, Sabine Warmuth, Marco Malavolta, Eugenio Mocchegiani, Lothar Rink.   

Abstract

Mild zinc deficiency is a common condition in healthy elderly individuals leading to impaired cell-mediated immune response. Here we report the effect of improved zinc status on TH1/TH2 balance and on the activation status of T helper cells in 19 healthy elderly subjects aged 69.8 +/- 5.1 years. Our investigations revealed a mild zinc deficiency which was adjusted by oral zinc supplementation for seven weeks. Improved serum zinc levels significantly reduced levels of activated T helper cells whereas changes in TH1/TH2 ratio (determined by CCR4 and CCR5 expression) were not observed. These findings suggest that elderly individuals may benefit from moderate zinc supplementation due to improved immune response leading to reduced incidences of autoimmune diseases and infections.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16967204     DOI： 10.1007/s10522-006-9058-2

Source DB:  PubMed          Journal:  Biogerontology        ISSN： 1389-5729            Impact factor:   4.277


  11 in total

Review 1.  Zinc: dietary intake and impact of supplementation on immune function in elderly.

Authors:  Eugenio Mocchegiani; Javier Romeo; Marco Malavolta; Laura Costarelli; Robertina Giacconi; Ligia-Esperanza Diaz; Ascension Marcos
Journal:  Age (Dordr)       Date:  2012-01-06

2.  The role of nutrition in enhancing immunity in aging.

Authors:  Munkyong Pae; Simin Nikbin Meydani; Dayong Wu
Journal:  Aging Dis       Date:  2011-09-30       Impact factor: 6.745

3.  Zinc supplementation induces CD4+CD25+Foxp3+ antigen-specific regulatory T cells and suppresses IFN-γ production by upregulation of Foxp3 and KLF-10 and downregulation of IRF-1.

Authors:  Martina Maywald; Lothar Rink
Journal:  Eur J Nutr       Date:  2016-06-03       Impact factor: 5.614

4.  Main biomarkers associated with age-related plasma zinc decrease and copper/zinc ratio in healthy elderly from ZincAge study.

Authors:  R Giacconi; L Costarelli; F Piacenza; A Basso; L Rink; E Mariani; T Fulop; G Dedoussis; G Herbein; M Provinciali; J Jajte; I Lengyel; E Mocchegiani; M Malavolta
Journal:  Eur J Nutr       Date:  2016-07-26       Impact factor: 5.614

5.  Lower Plasma Zinc Levels in Hyperglycemic People Living with HIV in the MASH cohort.

Authors:  Alicia Sneij; Adriana Campa; Sabrina Sales Martinez; Tiffanie Stewart; Marianna Baum
Journal:  J AIDS Clin Res       Date:  2016-02-15

6.  Implications of compromised zinc status on bone loss associated with chronic inflammation in C57BL/6 mice.

Authors:  Pitipa Chongwatpol; Elizabeth Rendina-Ruedy; Barbara J Stoecker; Stephen L Clarke; Edralin A Lucas; Brenda J Smith
Journal:  J Inflamm Res       Date:  2015-07-13

Review 7.  Nutritional Modulation of Immune Function: Analysis of Evidence, Mechanisms, and Clinical Relevance.

Authors:  Dayong Wu; Erin D Lewis; Munyong Pae; Simin Nikbin Meydani
Journal:  Front Immunol       Date:  2019-01-15       Impact factor: 7.561

Review 8.  Mineral Micronutrients in Asthma.

Authors:  Dominika Zajac
Journal:  Nutrients       Date:  2021-11-10       Impact factor: 5.717

9.  The immune system and the impact of zinc during aging.

Authors:  Hajo Haase; Lothar Rink
Journal:  Immun Ageing       Date:  2009-06-12       Impact factor: 6.400

10.  Leptin and zinc relation: In regulation of food intake and immunity.

Authors:  Abdulkerim Kasim Baltaci; Rasim Mogulkoc
Journal:  Indian J Endocrinol Metab       Date:  2012-12
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.