Literature DB >> 16965385

The MLL partial tandem duplication in acute myeloid leukaemia.

Jorg Basecke1, Jarrett T Whelan, Frank Griesinger, Fred E Bertrand.   

Abstract

Mixed lineage leukaemia gene-partial tandem duplications (MLL-PTD) characterise acute myeloid leukaemia (AML) with trisomy 11 and AML with a normal karyotype. MLL-PTD confer a worse prognosis with shortened overall and event free survival in childhood and adult AML. In spite of these clinical observations, the leukaemogenic mechanism has, so far, not been determined. This review summarises clinical studies on MLL-PTD positive AML and recent experimental findings on the putative leukaemogenic role of MLL-PTD.

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Year:  2006        PMID： 16965385     DOI： 10.1111/j.1365-2141.2006.06301.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  28 in total

1.  Grist for the MLL: how do MLL oncogenic fusion proteins generate leukemia stem cells?

Authors:  Tim C P Somervaille; Michael L Cleary
Journal:  Int J Hematol       Date:  2010-05-08       Impact factor: 2.490

2.  Dynamic single-cell network profiles in acute myelogenous leukemia are associated with patient response to standard induction therapy.

Authors:  Steven M Kornblau; Mark D Minden; David B Rosen; Santosh Putta; Aileen Cohen; Todd Covey; David C Spellmeyer; Wendy J Fantl; Urte Gayko; Alessandra Cesano
Journal:  Clin Cancer Res       Date:  2010-06-04       Impact factor: 12.531

3.  Evaluation of gene expression signatures predictive of cytogenetic and molecular subtypes of pediatric acute myeloid leukemia.

Authors:  Brian V Balgobind; Marry M Van den Heuvel-Eibrink; Renee X De Menezes; Dirk Reinhardt; Iris H I M Hollink; Susan T J C M Arentsen-Peters; Elisabeth R van Wering; Gertjan J L Kaspers; Jacqueline Cloos; Evelien S J M de Bont; Jean-Michel Cayuela; Andre Baruchel; Claus Meyer; Rolf Marschalek; Jan Trka; Jan Stary; H Berna Beverloo; Rob Pieters; C Michel Zwaan; Monique L den Boer
Journal:  Haematologica       Date:  2010-10-22       Impact factor: 9.941

Review 4.  The pathogenesis of mixed-lineage leukemia.

Authors:  Andrew G Muntean; Jay L Hess
Journal:  Annu Rev Pathol       Date:  2011-10-17       Impact factor: 23.472

5.  Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells.

Authors:  Yue Zhang; Xiaomei Yan; Goro Sashida; Xinghui Zhao; Yalan Rao; Susumu Goyama; Susan P Whitman; Nicholas Zorko; Kelsie Bernot; Rajeana M Conway; David Witte; Qian-Fei Wang; Daniel G Tenen; Zhijian Xiao; Guido Marcucci; James C Mulloy; H Leighton Grimes; Michael A Caligiuri; Gang Huang
Journal:  Blood       Date:  2012-06-26       Impact factor: 22.113

Review 6.  Genetic tests to evaluate prognosis and predict therapeutic response in acute myeloid leukemia.

Authors:  Margaret L Gulley; Thomas C Shea; Yuri Fedoriw
Journal:  J Mol Diagn       Date:  2009-12-03       Impact factor: 5.568

Review 7.  Is it important to decipher the heterogeneity of "normal karyotype AML"?

Authors:  Stephen D Nimer
Journal:  Best Pract Res Clin Haematol       Date:  2008-03       Impact factor: 3.020

8.  Allogeneic stem cell transplantation in acute myeloid leukemia: establishment of indications on the basis of individual risk stratification.

Authors:  Axel Rolf Zander; Ulrike Bacher; Jürgen Finke
Journal:  Dtsch Arztebl Int       Date:  2008-09-26       Impact factor: 5.594

Review 9.  The molecular biology of mixed lineage leukemia.

Authors:  Robert K Slany
Journal:  Haematologica       Date:  2009-06-16       Impact factor: 9.941

10.  Acute myeloid leukemia with t(10;11): a pathological entity with distinct clinical presentation.

Authors:  Courtney D DiNardo; Guilin Tang; Naveen Pemmaraju; Sa A Wang; Allison Pike; Guillermo Garcia-Manero; Jorge Cortes; Carlos Bueso-Ramos; Hagop M Kantarjian
Journal:  Clin Lymphoma Myeloma Leuk       Date:  2014-06-21
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