Literature DB >> 16963187

Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms.

Galina I Lepesheva1, Michael R Waterman.   

Abstract

The CYP51 family is an intriguing subject for fundamental P450 structure/function studies and is also an important clinical drug target. This review updates information on the variety of the CYP51 family members, including their physiological roles, natural substrates and substrate preferences, and catalytic properties in vitro. We present experimental support for the notion that specific conserved regions in the P450 sequences represent a CYP51 signature. Two possible roles of CYP51 in P450 evolution are discussed and the major approaches for CYP51 inhibition are summarized.

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Year:  2006        PMID： 16963187      PMCID： PMC2324071          DOI： 10.1016/j.bbagen.2006.07.018

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  76 in total

1.  Formation of azole-resistant Candida albicans by mutation of sterol 14-demethylase P450.

Authors:  K Asai; N Tsuchimori; K Okonogi; J R Perfect; O Gotoh; Y Yoshida
Journal:  Antimicrob Agents Chemother       Date:  1999-05       Impact factor: 5.191

2.  Expression, purification, reconstitution and inhibition of Ustilago maydis sterol 14 alpha-demethylase (CYP51; P450(14DM)).

Authors:  D C Lamb; D E Kelly; N J Manning; D W Hollomon; S L Kelly
Journal:  FEMS Microbiol Lett       Date:  1998-12-15       Impact factor: 2.742

3.  CYP51-like gene of Mycobacterium tuberculosis actually encodes a P450 similar to eukaryotic CYP51.

Authors:  Y Aoyama; T Horiuchi; O Gotoh; M Noshiro; Y Yoshida
Journal:  J Biochem       Date:  1998-10       Impact factor: 3.387

4.  Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase: II. Evolutionary analysis of protein and gene structures.

Authors:  Y Yoshida; M Noshiro; Y Aoyama; T Kawamoto; T Horiuchi; O Gotoh
Journal:  J Biochem       Date:  1997-12       Impact factor: 3.387

5.  Elevated expression of lanosterol 14alpha-demethylase (CYP51) and the synthesis of oocyte meiosis-activating sterols in postmeiotic germ cells of male rats.

Authors:  M Strömstedt; M R Waterman; T B Haugen; K Taskén; M Parvinen; D Rozman
Journal:  Endocrinology       Date:  1998-05       Impact factor: 4.736

6.  Characterization of Saccharomyces cerevisiae CYP61, sterol delta22-desaturase, and inhibition by azole antifungal agents.

Authors:  S L Kelly; D C Lamb; B C Baldwin; A J Corran; D E Kelly
Journal:  J Biol Chem       Date:  1997-04-11       Impact factor: 5.157

7.  The three human cytochrome P450 lanosterol 14 alpha-demethylase (CYP51) genes reside on chromosomes 3, 7, and 13: structure of the two retrotransposed pseudogenes, association with a line-1 element, and evolution of the human CYP51 family.

Authors:  D Rozman; M Strömstedt; M R Waterman
Journal:  Arch Biochem Biophys       Date:  1996-09-15       Impact factor: 4.013

8.  Isolation and reconstitution of the heme-thiolate protein obtusifoliol 14alpha-demethylase from Sorghum bicolor (L.) Moench.

Authors:  R A Kahn; S Bak; C E Olsen; I Svendsen; B L Moller
Journal:  J Biol Chem       Date:  1996-12-20       Impact factor: 5.157

9.  Cure of short- and long-term experimental Chagas' disease using D0870.

Authors:  J A Urbina; G Payares; J Molina; C Sanoja; A Liendo; K Lazardi; M M Piras; R Piras; N Perez; P Wincker; J F Ryley
Journal:  Science       Date:  1996-08-16       Impact factor: 47.728

10.  Understanding the role of the essential Asp251 in cytochrome p450cam using site-directed mutagenesis, crystallography, and kinetic solvent isotope effect.

Authors:  M Vidakovic; S G Sligar; H Li; T L Poulos
Journal:  Biochemistry       Date:  1998-06-30       Impact factor: 3.162
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  131 in total

1.  Substrate preferences and catalytic parameters determined by structural characteristics of sterol 14alpha-demethylase (CYP51) from Leishmania infantum.

Authors:  Tatiana Y Hargrove; Zdzislaw Wawrzak; Jialin Liu; W David Nes; Michael R Waterman; Galina I Lepesheva
Journal:  J Biol Chem       Date:  2011-05-31       Impact factor: 5.157

2.  Structural insights into inhibition of sterol 14alpha-demethylase in the human pathogen Trypanosoma cruzi.

Authors:  Galina I Lepesheva; Tatiana Y Hargrove; Spencer Anderson; Yuliya Kleshchenko; Vyacheslav Furtak; Zdzislaw Wawrzak; Fernando Villalta; Michael R Waterman
Journal:  J Biol Chem       Date:  2010-06-08       Impact factor: 5.157

Review 3.  The Mycobacterium tuberculosis cytochrome P450 system.

Authors:  Hugues Ouellet; Jonathan B Johnston; Paul R Ortiz de Montellano
Journal:  Arch Biochem Biophys       Date:  2009-07-25       Impact factor: 4.013

Review 4.  Targeting Trypanosoma cruzi sterol 14α-demethylase (CYP51).

Authors:  Galina I Lepesheva; Fernando Villalta; Michael R Waterman
Journal:  Adv Parasitol       Date:  2011       Impact factor: 3.870

5.  Structural insights into the mechanism of the drastic changes in enzymatic activity of the cytochrome P450 vitamin D3 hydroxylase (CYP107BR1) caused by a mutation distant from the active site.

Authors:  Yoshiaki Yasutake; Tomoshi Kameda; Tomohiro Tamura
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2017-04-26       Impact factor: 1.056

6.  A requirement for an active proton delivery network supports a compound I-mediated C-C bond cleavage in CYP51 catalysis.

Authors:  Tatiana Y Hargrove; Zdzislaw Wawrzak; F Peter Guengerich; Galina I Lepesheva
Journal:  J Biol Chem       Date:  2020-06-03       Impact factor: 5.157

7.  Complexes of Trypanosoma cruzi sterol 14α-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: structural basis for pathogen selectivity.

Authors:  Tatiana Y Hargrove; Zdzislaw Wawrzak; Paul W Alexander; Jason H Chaplin; Martine Keenan; Susan A Charman; Catherine J Perez; Michael R Waterman; Eric Chatelain; Galina I Lepesheva
Journal:  J Biol Chem       Date:  2013-09-18       Impact factor: 5.157

Review 8.  PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid signaling, P450 activation and drug binding.

Authors:  Hannah J Rohe; Ikhlas S Ahmed; Katherine E Twist; Rolf J Craven
Journal:  Pharmacol Ther       Date:  2008-11-01       Impact factor: 12.310

9.  Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae.

Authors:  Laura Friggeri; Tatiana Y Hargrove; Girish Rachakonda; Anna L Blobaum; Paxtyn Fisher; Gabriel Melo de Oliveira; Cristiane França da Silva; Maria de Nazaré C Soeiro; W David Nes; Craig W Lindsley; Fernando Villalta; F Peter Guengerich; Galina I Lepesheva
Journal:  J Med Chem       Date:  2018-11-30       Impact factor: 7.446

10.  The first virally encoded cytochrome p450.

Authors:  David C Lamb; Li Lei; Andrew G S Warrilow; Galina I Lepesheva; Jonathan G L Mullins; Michael R Waterman; Steven L Kelly
Journal:  J Virol       Date:  2009-06-10       Impact factor: 5.103
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