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Literature DB >> 16960651

Insight and regional brain volumes in schizophrenia.

Débora Pastore Bassitt¹, Mario Rodrigues Louzä Neto, Cláudio Campi de Castro, Geraldo F Busatto.

Abstract

We have investigated the relationship between insight impairment and regional brain volumes (gray and white matter) in schizophrenia using voxel-based morphometry (VBM). Fifty patients with schizophrenia were evaluated using the Scale for Unawareness of Mental Disorders. Magnetic resonance images were acquired, segmented and spatially normalized using optimized VBM routines. No significant inverse correlations were detected between insight impairment and gray or white matter volumes in the prefrontal region (where significant findings had been predicted a priori), or in any other brain areas. Our results do not support previous hypotheses suggesting a relationship between frontal lobe atrophy and impaired insight in patients with schizophrenia.

Entities: Disease Species

Mesh：

Year: 2007 PMID： 16960651 DOI： 10.1007/s00406-006-0685-z

Source DB: PubMed Journal: Eur Arch Psychiatry Clin Neurosci ISSN： 0940-1334 Impact factor: 5.270

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