Literature DB >> 16956606

Zyxin is upregulated in the nucleus by thymosin beta4 in SiHa cells.

Hye-Sung Moon1, Sharona Even-Ram, Hynda K Kleinman, Hee-Jae Cha.   

Abstract

Thymosin beta4 is a 43-amino acid actin-binding protein that promotes cell migration and is important in angiogenesis, wound healing, and tumor metastasis. We searched for genes upregulated by thymosin beta4 and identified zyxin as increased in SiHa cells in the presence of exogenously added thymosin beta4 and when thymosin beta4 is overexpressed using adenoviral vectors. Both zyxin and thymosin beta4 show increased localization in the nucleus. We conclude that thymosin beta4 may exert some of its migration promoting activity via increased zyxin expression.

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Year:  2006        PMID： 16956606     DOI： 10.1016/j.yexcr.2006.07.021

Source DB:  PubMed          Journal:  Exp Cell Res        ISSN： 0014-4827            Impact factor:   3.905


  9 in total

1.  Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK.

Authors:  Ping Qiu; Michelle Kurpakus Wheater; Yue Qiu; Gabriel Sosne
Journal:  FASEB J       Date:  2011-02-22       Impact factor: 5.191

2.  Expression of Zyxin in Non-Small Cell Lung Cancer-A Preliminary Study.

Authors:  Aleksandra Partynska; Agnieszka Gomulkiewicz; Aleksandra Piotrowska; Jedrzej Grzegrzolka; Adam Rzechonek; Katarzyna Ratajczak-Wielgomas; Marzenna Podhorska-Okolow; Piotr Dziegiel
Journal:  Biomolecules       Date:  2022-06-13

3.  Different thymosin Beta 4 immunoreactivity in foetal and adult gastrointestinal tract.

Authors:  Sonia Nemolato; Tiziana Cabras; Flaviana Cau; Mattia Umberto Fanari; Daniela Fanni; Barbara Manconi; Irene Messana; Massimo Castagnola; Gavino Faa
Journal:  PLoS One       Date:  2010-02-09       Impact factor: 3.240

4.  Thymosin beta 4: A novel corneal wound healing and anti-inflammatory agent.

Authors:  Gabriel Sosne; Ping Qiu; Michelle Kurpakus-Wheater
Journal:  Clin Ophthalmol       Date:  2007-09

Review 5.  Cellular mechanosensing: getting to the nucleus of it all.

Authors:  Gregory R Fedorchak; Ashley Kaminski; Jan Lammerding
Journal:  Prog Biophys Mol Biol       Date:  2014-07-05       Impact factor: 3.667

6.  Molecular characterization, tissue distribution, subcellular localization and actin-sequestering function of a thymosin protein from silkworm.

Authors:  Wenping Zhang; Changrong Zhang; Zhengbing Lv; Dailing Fang; Dan Wang; Zuoming Nie; Wei Yu; Hanglian Lan; Caiying Jiang; Yaozhou Zhang
Journal:  PLoS One       Date:  2012-02-22       Impact factor: 3.240

7.  A Tobacco-Derived Thymosin β4 Concatemer Promotes Cell Proliferation and Wound Healing in Mice.

Authors:  Rylosona Janarthini; Xiaolei Wang; Lulu Chen; Lei Gao; Lingxia Zhao
Journal:  Biomed Res Int       Date:  2016-07-14       Impact factor: 3.411

8.  Global Proteomics-based Identification and Validation of Thymosin Beta-4 X-Linked as a Prognostic Marker for Head and Neck Squamous Cell Carcinoma.

Authors:  Li-Hsing Chi; Wei-Min Chang; Yu-Chan Chang; Yung-Chieh Chan; Chia-Chen Tai; Kam-Wing Leung; Chi-Long Chen; Alexander Th Wu; Tsung-Ching Lai; Yu-Chuan Jack Li; Michael Hsiao
Journal:  Sci Rep       Date:  2017-08-22       Impact factor: 4.379

Review 9.  Thymus-Pineal Gland Axis: Revisiting Its Role in Human Life and Ageing.

Authors:  Rita Rezzani; Caterina Franco; Rüdiger Hardeland; Luigi Fabrizio Rodella
Journal:  Int J Mol Sci       Date:  2020-11-20       Impact factor: 5.923
  9 in total

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