AIM: The aim of this study was to investigate the association between the presence of ApoE4 and the incidence of postoperative cognitive dysfunction (POCD) after cardiac surgery. METHODS: Eighty-seven adult patients undergoing elective coronary artery bypass graft surgery were observed prospectively at a university tertiary care hospital. All patients were evaluated with the Mini-Mental State Examination (MMSE) and the Glasgow Coma Scale (GCS) for cognitive function and mental status preoperatively, 24 h after surgery and at postoperative day 6. Patients were genotyped for the ApoE polymorphism. The association between ApoE genotype and MMSE evolution was studied by using repeated measures ANOVA. RESULTS: Both the presence of at least one ApoE4 allele and POCD were verified in 21.8% of subjects. The presence of the ApoE4 allele was significantly associated with a worse MMSE score evolution (P=0.04). CONCLUSION: This study suggests an association between ApoE4 and early POCD, but further studies are needed to clarify a causative association. Such new studies should include a more homogenous patient sample and a longer follow-up.
AIM: The aim of this study was to investigate the association between the presence of ApoE4 and the incidence of postoperative cognitive dysfunction (POCD) after cardiac surgery. METHODS: Eighty-seven adult patients undergoing elective coronary artery bypass graft surgery were observed prospectively at a university tertiary care hospital. All patients were evaluated with the Mini-Mental State Examination (MMSE) and the Glasgow Coma Scale (GCS) for cognitive function and mental status preoperatively, 24 h after surgery and at postoperative day 6. Patients were genotyped for the ApoE polymorphism. The association between ApoE genotype and MMSE evolution was studied by using repeated measures ANOVA. RESULTS: Both the presence of at least one ApoE4 allele and POCD were verified in 21.8% of subjects. The presence of the ApoE4 allele was significantly associated with a worse MMSE score evolution (P=0.04). CONCLUSION: This study suggests an association between ApoE4 and early POCD, but further studies are needed to clarify a causative association. Such new studies should include a more homogenous patient sample and a longer follow-up.
Authors: Gene T Yocum; John G Gaudet; Susie S Lee; Yaakov Stern; Lauren A Teverbaugh; Robert R Sciacca; Charles W Emala; Donald O Quest; Paul C McCormick; James F McKinsey; Nicholas J Morrissey; Robert A Solomon; E Sander Connolly; Eric J Heyer Journal: Stroke Date: 2009-03-12 Impact factor: 7.914
Authors: Niccolò Terrando; Marek Brzezinski; Vincent Degos; Lars I Eriksson; Joel H Kramer; Jacqueline M Leung; Bruce L Miller; William W Seeley; Susana Vacas; Michael W Weiner; Kristine Yaffe; William L Young; Zhongcong Xie; Mervyn Maze Journal: Mayo Clin Proc Date: 2011-09 Impact factor: 7.616
Authors: G I Tagarakis; F Tsolaki-Tagaraki; M Tsolaki; A Diegeler; D Kazis; E Rouska; A Papassotiropoulos Journal: Clin Res Cardiol Date: 2007-06-27 Impact factor: 5.460
Authors: Kirk J Hogan; James K Burmester; Michael D Caldwell; Quinn H Hogan; Douglas B Coursin; Dawn N Green; Rebecca M R Selzer; Thomas P Broderick; Deborah A Rusy; Mark Poroli; Anna L Lutz; Allison M Sanders; Mary C Oldenburg; James A Koelbl; Monika de Arruda-Indig; Jennifer L Halsey; Stephen P Day; Michael J Domanico Journal: Clin Med Res Date: 2009-05-27