| Literature DB >> 16952773 |
David A Brent1, Boris Birmaher.
Abstract
Approximately 20% of adolescents experience at least one depressive episode by the time they enter their adult years. For most adolescents, depression, although serious, either remits spontaneously or responds to treatment. For a smaller but significant proportion of adolescents, however, depression can be long-lasting and relatively unresponsive to initial treatment. In this article the authors provide an operational definition of treatment-resistant depression, identify factors associated with treatment nonresponse, describe an approach to the management of treatment-resistant depression, and advance suggestions for promising avenues of research.Entities:
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Year: 2006 PMID： 16952773 DOI： 10.1016/j.chc.2006.05.001
Source DB: PubMed Journal: Child Adolesc Psychiatr Clin N Am ISSN： 1056-4993