Literature DB >> 16950919

The cytotoxic fimbrial structural subunit of Xenorhabdus nematophila is a pore-forming toxin.

Jyotirmoy Banerjee1, Jitendra Singh, Mohan Chandra Joshi, Shubhendu Ghosh, Nirupama Banerjee.   

Abstract

We have purified a fimbrial shaft protein (MrxA) of Xenorhabdus nematophila. The soluble monomeric protein lysed larval hemocytes of Helicoverpa armigera. Osmotic protection of the cells with polyethylene glycol suggested that the 17-kDa MrxA subunit makes pores in the target cell membrane. The internal diameter of the pores was estimated to be >2.9 nm. Electron microscopy confirmed the formation of pores by the fimbrial subunit. MrxA protein oligomerized in the presence of liposomes. Electrophysiological studies demonstrated that MrxA formed large, voltage-gated passive-diffusion channels in lipid bilayers.

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Year:  2006        PMID： 16950919      PMCID： PMC1636316          DOI： 10.1128/JB.00787-06

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  35 in total

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Journal:  Curr Top Microbiol Immunol       Date:  2001       Impact factor: 4.291

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Journal:  Microbiol Rev       Date:  1996-03

4.  Penetrating insights into pore formation.

Authors:  F M Hughson
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Review 5.  Channel-forming toxins: tales of transformation.

Authors:  E Gouaux
Journal:  Curr Opin Struct Biol       Date:  1997-08       Impact factor: 6.809

Review 6.  Membrane insertion: The strategies of toxins (review).

Authors:  C Lesieur; B Vécsey-Semjén; L Abrami; M Fivaz; F Gisou van der Goot
Journal:  Mol Membr Biol       Date:  1997 Apr-Jun       Impact factor: 2.857

7.  Sequence analysis of insecticidal genes from Xenorhabdus nematophilus PMFI296.

Authors:  J A Morgan; M Sergeant; D Ellis; M Ousley; P Jarrett
Journal:  Appl Environ Microbiol       Date:  2001-05       Impact factor: 4.792

8.  A reinterpretation of mammalian sodium channel gating based on single channel recording.

Authors:  R W Aldrich; D P Corey; C F Stevens
Journal:  Nature       Date:  1983 Dec 1-7       Impact factor: 49.962

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Authors:  J Brillard; C Ribeiro; N Boemare; M Brehélin; A Givaudan
Journal:  Appl Environ Microbiol       Date:  2001-06       Impact factor: 4.792

10.  Complement activation and attack on autologous cell membranes induced by streptolysin-O.

Authors:  S Bhakdi; J Tranum-Jensen
Journal:  Infect Immun       Date:  1985-06       Impact factor: 3.441
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  6 in total

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Authors:  Holly Snyder; Hongjun He; Heather Owen; Chris Hanna; Steven Forst
Journal:  Appl Environ Microbiol       Date:  2011-08-19       Impact factor: 4.792

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Journal:  Plant Cell Rep       Date:  2015-07-12       Impact factor: 4.570

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Journal:  J Bacteriol       Date:  2013-01-18       Impact factor: 3.490

5.  In Vivo Effects of A Pro-PO System Inhibitor on the Phagocytosis of Xenorhabdus Nematophila in Galleria Mellonella Larvae.

Authors:  Andrea De Lerma Barbaro; Marzia B Gariboldi; Maristella Mastore; Maurizio F Brivio; Stefano Giovannardi
Journal:  Insects       Date:  2019-08-22       Impact factor: 2.769

6.  NetB, a new toxin that is associated with avian necrotic enteritis caused by Clostridium perfringens.

Authors:  Anthony L Keyburn; John D Boyce; Paola Vaz; Trudi L Bannam; Mark E Ford; Dane Parker; Antonio Di Rubbo; Julian I Rood; Robert J Moore
Journal:  PLoS Pathog       Date:  2008-02-08       Impact factor: 6.823
  6 in total

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