| Literature DB >> 16950623 |
Marienca Femenía-Ríos1, Carlos M García-Pajón, Rosario Hernández-Galán, Antonio J Macías-Sánchez, Isidro G Collado.
Abstract
A novel metabolite (-)-1 was isolated as its peracetylated derivative, (-)-2-(3',4'-diacetoxyphenyl)-3,4-diacetoxytetrahydrofuran (2), from a strain of the phytopathogenic fungus Colletotrichum gloeosporioides CECT 20122. The synthesis of (-)-1 was carried out by ring-closing metathesis of diene 6 and stereoselective dihydroxylation of a dihydrofuran derivative 7 as key steps. The tetraol (-)-1 showed free radical scavenging activity comparable to that of BHT, caffeic acid or protocatechuic acid.Entities:
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Year: 2006 PMID： 16950623 DOI： 10.1016/j.bmcl.2006.08.071
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823