PURPOSE: To determine the association between change from baseline in the optic nerve head (ONH) and the visual field (VF) during follow-up of ocular hypertension participants in the Ocular Hypertension Treatment Study. DESIGN: Longitudinal randomized clinical trial. PARTICIPANTS: One hundred sixty-eight eyes of 152 ocular hypertensive participants ages 40 to 80 years. METHODS: Cox hazard models were applied to 3232 eyes, which included 81 eyes that reached a study end point by developing a glaucomatous VF (VF end point) and 128 eyes that reached a study end point by developing an optic disc change (optic disc end point). MAIN OUTCOME MEASURES: Primary open-angle glaucoma end point as determined by changes in the VF or optic disc. RESULTS: Forty-one eyes reached an end point by both VF and optic disc criteria; 40 eyes reached only a VF end point, and 87 reached only an optic disc end point. Times to reach isolated disc or field end points were similar. Visual field end points were more likely (P<0.0001) in eyes that showed the following ONH features: an ONH hemorrhage, thinning of the optic disc rim, or enlargement of the horizontal cup-to-disc (C/D) ratio. Optic disc end points were more likely (P<0.0001) in eyes that showed the following VF features: some evidence of a nasal step or a partial arcuate VF defect, or an increase in the pattern standard deviation (PSD). CONCLUSIONS: Both the VF and the optic disc must be monitored with equal diligence, because either may show the first evidence of glaucomatous damage. Changes in the ONH based on stereophotographic observation (rim thinning, hemorrhage, or a slight increase in C/D ratio) and VF changes (evidence of a nasal step/partial arcuate defect or an increase in PSD) suggest that these cases have an increased risk of developing glaucoma. Confirmation of such subtle findings should be sought through repeat testing and correlation with other clinical results.
RCT Entities:
PURPOSE: To determine the association between change from baseline in the optic nerve head (ONH) and the visual field (VF) during follow-up of ocular hypertensionparticipants in the Ocular Hypertension Treatment Study. DESIGN: Longitudinal randomized clinical trial. PARTICIPANTS: One hundred sixty-eight eyes of 152 ocular hypertensiveparticipants ages 40 to 80 years. METHODS: Cox hazard models were applied to 3232 eyes, which included 81 eyes that reached a study end point by developing a glaucomatous VF (VF end point) and 128 eyes that reached a study end point by developing an optic disc change (optic disc end point). MAIN OUTCOME MEASURES: Primary open-angle glaucoma end point as determined by changes in the VF or optic disc. RESULTS: Forty-one eyes reached an end point by both VF and optic disc criteria; 40 eyes reached only a VF end point, and 87 reached only an optic disc end point. Times to reach isolated disc or field end points were similar. Visual field end points were more likely (P<0.0001) in eyes that showed the following ONH features: an ONH hemorrhage, thinning of the optic disc rim, or enlargement of the horizontal cup-to-disc (C/D) ratio. Optic disc end points were more likely (P<0.0001) in eyes that showed the following VF features: some evidence of a nasal step or a partial arcuate VF defect, or an increase in the pattern standard deviation (PSD). CONCLUSIONS: Both the VF and the optic disc must be monitored with equal diligence, because either may show the first evidence of glaucomatous damage. Changes in the ONH based on stereophotographic observation (rim thinning, hemorrhage, or a slight increase in C/D ratio) and VF changes (evidence of a nasal step/partial arcuate defect or an increase in PSD) suggest that these cases have an increased risk of developing glaucoma. Confirmation of such subtle findings should be sought through repeat testing and correlation with other clinical results.
Authors: Patrick H W Chu; Yiu-fai Ng; Chi-ho To; Kwok-fai So; Brian Brown; Henry H L Chan Journal: Graefes Arch Clin Exp Ophthalmol Date: 2011-09-01 Impact factor: 3.117
Authors: Lilian Hui Li Koh; Muhammad Amir Ismail; Sae Cheong Yap; Elizabeth Poh Ying Wong; Leonard Wei Leon Yip Journal: Int J Ophthalmol Date: 2016-08-18 Impact factor: 1.779
Authors: Linda Yi-Chieh Poon; David Solá-Del Valle; Angela V Turalba; Iryna A Falkenstein; Michael Horsley; Julie H Kim; Brian J Song; Hana L Takusagawa; Kaidi Wang; Teresa C Chen Journal: Am J Ophthalmol Date: 2017-09-23 Impact factor: 5.258
Authors: Wishal D Ramdas; Leonieke M E van Koolwijk; M Kamran Ikram; Nomdo M Jansonius; Paulus T V M de Jong; Arthur A B Bergen; Aaron Isaacs; Najaf Amin; Yurii S Aulchenko; Roger C W Wolfs; Albert Hofman; Fernando Rivadeneira; Ben A Oostra; Andre G Uitterlinden; Pirro Hysi; Christopher J Hammond; Hans G Lemij; Johannes R Vingerling; Caroline C W Klaver; Cornelia M van Duijn Journal: PLoS Genet Date: 2010-06-10 Impact factor: 5.917