Literature DB >> 16947085

Notch signaling in breast cancer and tumor angiogenesis: cross-talk and therapeutic potentials.

Wen Shi1, Adrian L Harris.   

Abstract

Notch signaling is an evolutionarily conserved pathway that regulates numerous physiological processes. Disruption of Notch has been implicated in multiple tumor types. Evidence from in vitro experiments, mouse models and human tumor samples indicates that Notch plays a predominantly oncogenic role in breast cancer and interacts with other pathways involved in tumorigenesis. In addition, Notch signaling is required for physiological angiogenesis and may promote tumor angiogenesis. A variety of strategies for blocking Notch signaling, in particular gamma-secretase inhibition, are discussed as potential therapies for breast cancer and tumor angiogenesis.

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Year:  2006        PMID： 16947085     DOI： 10.1007/s10911-006-9011-7

Source DB:  PubMed          Journal:  J Mammary Gland Biol Neoplasia        ISSN： 1083-3021            Impact factor:   2.673


  81 in total

1.  Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21Cip1 repression.

Authors:  Michela Noseda; Linda Chang; Graeme McLean; Jonathan E Grim; Bruce E Clurman; Laura L Smith; Aly Karsan
Journal:  Mol Cell Biol       Date:  2004-10       Impact factor: 4.272

2.  Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling.

Authors:  Qinghua Zeng; Shenglin Li; Douglas B Chepeha; Thomas J Giordano; Jong Li; Honglai Zhang; Peter J Polverini; Jacques Nor; Jan Kitajewski; Cun-Yu Wang
Journal:  Cancer Cell       Date:  2005-07       Impact factor: 31.743

3.  Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane.

Authors:  C M Blaumueller; H Qi; P Zagouras; S Artavanis-Tsakonas
Journal:  Cell       Date:  1997-07-25       Impact factor: 41.582

4.  Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice.

Authors:  Timothy R Carlson; Yibing Yan; Xiaoqing Wu; Michael T Lam; Gale L Tang; Levi J Beverly; Louis M Messina; Anthony J Capobianco; Zena Werb; Rong Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2005-06-30       Impact factor: 11.205

Review 5.  Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease.

Authors:  Johan H van Es; Hans Clevers
Journal:  Trends Mol Med       Date:  2005-10-07       Impact factor: 11.951

6.  Notch1 oncoprotein antagonizes TGF-beta/Smad-mediated cell growth suppression via sequestration of coactivator p300.

Authors:  Shigeo Masuda; Keiki Kumano; Kiyoshi Shimizu; Yoichi Imai; Mineo Kurokawa; Seishi Ogawa; Makoto Miyagishi; Kazunari Taira; Hisamaru Hirai; Shigeru Chiba
Journal:  Cancer Sci       Date:  2005-05       Impact factor: 6.716

7.  Mammary development and tumorigenesis in mice expressing a truncated human Notch4/Int3 intracellular domain (h-Int3sh).

Authors:  Ahmed Raafat; Sharon Bargo; Miriam R Anver; Robert Callahan
Journal:  Oncogene       Date:  2004-12-16       Impact factor: 9.867

8.  The Notch target genes Hey1 and Hey2 are required for embryonic vascular development.

Authors:  Andreas Fischer; Nina Schumacher; Manfred Maier; Michael Sendtner; Manfred Gessler
Journal:  Genes Dev       Date:  2004-04-15       Impact factor: 11.361

9.  TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.

Authors:  L W Ellisen; J Bird; D C West; A L Soreng; T C Reynolds; S D Smith; J Sklar
Journal:  Cell       Date:  1991-08-23       Impact factor: 41.582

10.  Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene.

Authors:  H Uyttendaele; G Marazzi; G Wu; Q Yan; D Sassoon; J Kitajewski
Journal:  Development       Date:  1996-07       Impact factor: 6.868
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  44 in total

1.  Notch2 signaling induces apoptosis and inhibits human MDA-MB-231 xenograft growth.

Authors:  Christine F O'Neill; Sumithra Urs; Christina Cinelli; Alexis Lincoln; Robert J Nadeau; Ruth León; Jessica Toher; Carla Mouta-Bellum; Robert E Friesel; Lucy Liaw
Journal:  Am J Pathol       Date:  2007-08-03       Impact factor: 4.307

2.  Kinetic insulation as an effective mechanism for achieving pathway specificity in intracellular signaling networks.

Authors:  Marcelo Behar; Henrik G Dohlman; Timothy C Elston
Journal:  Proc Natl Acad Sci U S A       Date:  2007-10-03       Impact factor: 11.205

Review 3.  Targeting γ-secretase in breast cancer.

Authors:  Jianxun Han; Qiang Shen
Journal:  Breast Cancer (Dove Med Press)       Date:  2012-06-21

4.  Long signaling cascades tend to attenuate retroactivity.

Authors:  Hamid R Ossareh; Alejandra C Ventura; Sofia D Merajver; Domitilla Del Vecchio
Journal:  Biophys J       Date:  2011-04-06       Impact factor: 4.033

Review 5.  microRNA regulation of human pancreatic cancer stem cells.

Authors:  Yi-Fan Xu; Bethany N Hannafon; Wei-Qun Ding
Journal:  Stem Cell Investig       Date:  2017-01-21

6.  γ-Secretase inhibition of murine choroidal neovascularization is associated with reduction of superoxide and proinflammatory cytokines.

Authors:  Xiaoping Qi; Jun Cai; Qing Ruan; Li Liu; Sanford L Boye; Zhijuan Chen; William W Hauswirth; Renee C Ryals; Lynn Shaw; Sergio Caballero; Maria B Grant; Michael E Boulton
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-02-01       Impact factor: 4.799

7.  Reinforcing targeted therapeutics with phenotypic stability factors.

Authors:  Paul Yaswen
Journal:  Cell Cycle       Date:  2014       Impact factor: 4.534

8.  DOXIL when combined with Withaferin A (WFA) targets ALDH1 positive cancer stem cells in ovarian cancer.

Authors:  Sham S Kakar; Christopher A Worth; Zhenglong Wang; Kelsey Carter; Mariusz Ratajczak; Pranesh Gunjal
Journal:  J Cancer Stem Cell Res       Date:  2016-04-19

9.  The cytotoxicity of gamma-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition.

Authors:  Jianxun Han; Ivy Ma; Michael J Hendzel; Joan Allalunis-Turner
Journal:  Breast Cancer Res       Date:  2009-08-06       Impact factor: 6.466

10.  Postmenopausal estrogen and progestin effects on the serum proteome.

Authors:  Sharon J Pitteri; Samir M Hanash; Aaron Aragaki; Lynn M Amon; Lin Chen; Tina Busald Buson; Sophie Paczesny; Hiroyuki Katayama; Hong Wang; Melissa M Johnson; Qing Zhang; Martin McIntosh; Pei Wang; Charles Kooperberg; Jacques E Rossouw; Rebecca D Jackson; Joann E Manson; Judith Hsia; Simin Liu; Lisa Martin; Ross L Prentice
Journal:  Genome Med       Date:  2009-12-24       Impact factor: 11.117
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