| Literature DB >> 16945540 |
Alan R Katritzky1, Liliana M Pacureanu, Svetoslav Slavov, Dimitar A Dobchev, Mati Karelson.
Abstract
A QSAR methodology that involves multilinear (Hansch-type) and nonlinear (ANN backpropagation) approaches was developed to correlate the antiplatelet activity of 60 benzoxazinone derivatives against factor Xa. The statistical characteristics provided by multilinear model (R2 = 0.821) indicated satisfactory stability and predictive ability, while the ANN predictive ability is somewhat superior (R2 = 0.909). The multilinear model provided insight into the main factors that modulate the inhibitory activity of the investigated compounds.Entities:
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Year: 2006 PMID： 16945540 DOI： 10.1016/j.bmc.2006.07.022
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641