OBJECTIVES: Mild cognitive impairment (MCI) is regarded as a precursor to dementia, but not all patients with MCI actually develop dementia. As Alzheimer and vascular dementia are thought to share many common etiopathogenetic mechanisms, we investigated whether the vascular risk factor atrial fibrillation affects the risk of conversion to dementia for different MCI subtypes diagnosed according to international criteria. METHODS: One hundred and eighty elderly outpatients with MCI and 431 elderly outpatients with a normal cognition were followed up for a mean of 3 and 4 years, respectively. The risk of conversion to dementia associated with atrial fibrillation was studied in both samples using a Cox proportional hazards model adjusted for socio-demographic and medical variables. RESULTS: Overall conversion rate to dementia was 10.5 (8.0-13.8 per 100 person-years) in the MCI group and 2.2 (1.5-3.1 per 100 person-years) in the normal cognition group. Atrial fibrillation was significantly associated with conversion to dementia [hazard ratio (HR): 4.63; 95% confidence interval: 1.72-12.46] in the MCI group but not in the cognitively normal group (HR: 1.10; 95% confidence interval: 0.40-3.03). DISCUSSION: Current diagnostic criteria for MCI subtypes define heterogeneous populations, but atrial fibrillation can be useful in identifying people with increased risk of conversion to dementia.
OBJECTIVES: Mild cognitive impairment (MCI) is regarded as a precursor to dementia, but not all patients with MCI actually develop dementia. As Alzheimer and vascular dementia are thought to share many common etiopathogenetic mechanisms, we investigated whether the vascular risk factor atrial fibrillation affects the risk of conversion to dementia for different MCI subtypes diagnosed according to international criteria. METHODS: One hundred and eighty elderly outpatients with MCI and 431 elderly outpatients with a normal cognition were followed up for a mean of 3 and 4 years, respectively. The risk of conversion to dementia associated with atrial fibrillation was studied in both samples using a Cox proportional hazards model adjusted for socio-demographic and medical variables. RESULTS: Overall conversion rate to dementia was 10.5 (8.0-13.8 per 100 person-years) in the MCI group and 2.2 (1.5-3.1 per 100 person-years) in the normal cognition group. Atrial fibrillation was significantly associated with conversion to dementia [hazard ratio (HR): 4.63; 95% confidence interval: 1.72-12.46] in the MCI group but not in the cognitively normal group (HR: 1.10; 95% confidence interval: 0.40-3.03). DISCUSSION: Current diagnostic criteria for MCI subtypes define heterogeneous populations, but atrial fibrillation can be useful in identifying people with increased risk of conversion to dementia.
Authors: Paul B Rosenberg; Michelle M Mielke; Brian Appleby; Esther Oh; Jeannie-Marie Leoutsakos; Constantine G Lyketsos Journal: Int J Geriatr Psychiatry Date: 2010-09-15 Impact factor: 3.485
Authors: Francis E Cambronero; Dandan Liu; Jacquelyn E Neal; Elizabeth E Moore; Katherine A Gifford; James G Terry; Sangeeta Nair; Kimberly R Pechman; Katie E Osborn; Timothy J Hohman; Susan P Bell; J David Sweatt; Thomas J Wang; Joshua A Beckman; John Jeffrey Carr; Angela L Jefferson Journal: Neurobiol Aging Date: 2018-02-20 Impact factor: 4.673
Authors: Sascha Dublin; Melissa L Anderson; Sebastien J Haneuse; Susan R Heckbert; Paul K Crane; John C S Breitner; Wayne McCormick; James D Bowen; Linda Teri; Susan M McCurry; Eric B Larson Journal: J Am Geriatr Soc Date: 2011-08-01 Impact factor: 5.562
Authors: Sascha Dublin; Melissa L Anderson; Susan R Heckbert; Rebecca A Hubbard; Joshua A Sonnen; Paul K Crane; Thomas J Montine; Eric B Larson Journal: J Gerontol A Biol Sci Med Sci Date: 2013-09-28 Impact factor: 6.053
Authors: S Gillette Guyonnet; G Abellan Van Kan; S Andrieu; J P Aquino; C Arbus; J P Becq; C Berr; S Bismuth; B Chamontin; T Dantoine; J F Dartigues; B Dubois; B Fraysse; T Hergueta; H Hanaire; C Jeandel; S Lagleyre; F Lala; F Nourhashemi; P J Ousset; F Portet; P Ritz; P Robert; Y Rolland; C Sanz; M Soto; J Touchon; B Vellas Journal: J Nutr Health Aging Date: 2008-10 Impact factor: 4.075
Authors: Rosebud O Roberts; Yonas E Geda; David S Knopman; Ruth H Cha; V Shane Pankratz; Bradley F Boeve; Eric G Tangalos; Robert J Ivnik; Michelle M Mielke; Ronald C Petersen Journal: JAMA Neurol Date: 2013-03-01 Impact factor: 18.302
Authors: P B Rosenberg; M M Mielke; J Tschanz; L Cook; Chris Corcoran; K M Hayden; M Norton; P V Rabins; R C Green; K A Welsh-Bohmer; J C S Breitner; R Munger; C G Lyketsos Journal: Am J Geriatr Psychiatry Date: 2008-11 Impact factor: 4.105