BACKGROUND/AIMS: Gingko biloba is an antioxidant substance which has antagonistic activity on platelet-activating factor. We aimed to investigate the antioxidant effect and the histopathologic changes caused by Gingko biloba on acetic acid-induced colitis. METHODS: Totally 22 rats were divided into three groups. Group 1 (n=7) served as the control group. Group 2 (n=7) and Group 3 (n=8) were given 2 ml/day of 4% acetic acid by intracolonic instillation for three days. Gingko biloba (100 mg/kg) was then given only to Group 3 intraperitoneally for three days. Oxidative stress was assessed by determinate tissue and serum malondialdehyde (MDA) levels, and colonic damage was assessed by histologic examination. RESULTS: Depth of necrosis, extent of necrosis, degree of inflammation, extent of inflammation, fibrosis and total histologic scores in Group 2 were significantly higher than in the control group (p<0.05). The same parameters were lower in Group 3 versus Group 2, but the difference was not significant. Tissue and serum MDA levels in Group 2 were significantly higher than Group 1 (p<0.01 and 0.05, respectively). Again, the same parameters in Group 3 were lower than in Group 2, but the difference was not significant statistically. CONCLUSIONS: Gingko biloba did not significantly affect histopathological and oxidative stress parameters in experimental colitis.
BACKGROUND/AIMS: Gingko biloba is an antioxidant substance which has antagonistic activity on platelet-activating factor. We aimed to investigate the antioxidant effect and the histopathologic changes caused by Gingko biloba on acetic acid-induced colitis. METHODS: Totally 22 rats were divided into three groups. Group 1 (n=7) served as the control group. Group 2 (n=7) and Group 3 (n=8) were given 2 ml/day of 4% acetic acid by intracolonic instillation for three days. Gingko biloba (100 mg/kg) was then given only to Group 3 intraperitoneally for three days. Oxidative stress was assessed by determinate tissue and serum malondialdehyde (MDA) levels, and colonic damage was assessed by histologic examination. RESULTS: Depth of necrosis, extent of necrosis, degree of inflammation, extent of inflammation, fibrosis and total histologic scores in Group 2 were significantly higher than in the control group (p<0.05). The same parameters were lower in Group 3 versus Group 2, but the difference was not significant. Tissue and serum MDA levels in Group 2 were significantly higher than Group 1 (p<0.01 and 0.05, respectively). Again, the same parameters in Group 3 were lower than in Group 2, but the difference was not significant statistically. CONCLUSIONS:Gingko biloba did not significantly affect histopathological and oxidative stress parameters in experimental colitis.
Authors: Venkata S Kotakadi; Yu Jin; Anne B Hofseth; Lei Ying; Xiangli Cui; Suresh Volate; Alexander Chumanevich; Patricia A Wood; Robert L Price; Anna McNeal; Udai P Singh; Narendra P Singh; Mitzi Nagarkatti; Prakash S Nagarkatti; Lydia E Matesic; Karine Auclair; Michael J Wargovich; Lorne J Hofseth Journal: Carcinogenesis Date: 2008-06-20 Impact factor: 4.944
Authors: Salim S Al-Rejaie; Hatem M Abuohashish; Maher M Al-Enazi; Abdullah H Al-Assaf; Mihir Y Parmar; Mohammed M Ahmed Journal: World J Gastroenterol Date: 2013-09-14 Impact factor: 5.742
Authors: Abdulaziz M Aleisa; Salim S Al-Rejaie; Hatem M Abuohashish; Mohammed S Ola; Mihir Y Parmar; Mohammed M Ahmed Journal: BMC Complement Altern Med Date: 2014-02-10 Impact factor: 3.659