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Literature DB >> 16940129

Identification of RNase 8 as a novel human antimicrobial protein.

Bente Rudolph¹, Rainer Podschun, Hany Sahly, Sabine Schubert, Jens M Schröder, Jürgen Harder.

Abstract

The antimicrobial activity of the human RNase A superfamily member RNase 8 was evaluated. Recombinant RNase 8 exhibited broad-spectrum microbicidal activity against potential pathogenic microorganisms (including multidrug-resistant strains) at micro- to nanomolar concentrations. Thus, RNase 8 was identified as a novel antimicrobial protein and may contribute to host defense.

Entities: Gene Species

Mesh：

Substances：

Year: 2006 PMID： 16940129 PMCID： PMC1563533 DOI： 10.1128/AAC.00246-06

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

15 in total

1. RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in placenta.

Authors: Jianzhi Zhang; Kimberly D Dyer; Helene F Rosenberg
Journal: Nucleic Acids Res Date: 2002-03-01 Impact factor: 16.971

Review 2. Antimicrobial polypeptides.

Authors: Tomas Ganz
Journal: J Leukoc Biol Date: 2003-07-15 Impact factor: 4.962

3. Improved prediction of signal peptides: SignalP 3.0.

Authors: Jannick Dyrløv Bendtsen; Henrik Nielsen; Gunnar von Heijne; Søren Brunak
Journal: J Mol Biol Date: 2004-07-16 Impact factor: 5.469

4. The mammalian ionic environment dictates microbial susceptibility to antimicrobial defense peptides.

Authors: Robert A Dorschner; Belen Lopez-Garcia; Andreas Peschel; Dirk Kraus; Kazuya Morikawa; Victor Nizet; Richard L Gallo
Journal: FASEB J Date: 2006-01 Impact factor: 5.191

Review 5. Defensins: antimicrobial peptides of innate immunity.

Authors: Tomas Ganz
Journal: Nat Rev Immunol Date: 2003-09 Impact factor: 53.106

6. Burkholderia is highly resistant to human Beta-defensin 3.

Authors: Hany Sahly; Sabine Schubert; Jürgen Harder; Peter Rautenberg; Uwe Ullmann; Jens Schröder; Rainer Podschun
Journal: Antimicrob Agents Chemother Date: 2003-05 Impact factor: 5.191

7. Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic.

Authors: J Harder; J Bartels; E Christophers; J M Schroder
Journal: J Biol Chem Date: 2000-11-20 Impact factor: 5.157

8. Angiogenins: a new class of microbicidal proteins involved in innate immunity.

Authors: Lora V Hooper; Thaddeus S Stappenbeck; Chieu V Hong; Jeffrey I Gordon
Journal: Nat Immunol Date: 2003-01-27 Impact factor: 25.606

Review 9. Histatins: antimicrobial peptides with therapeutic potential.

Authors: Kevin Kavanagh; Susan Dowd
Journal: J Pharm Pharmacol Date: 2004-03 Impact factor: 3.765

10. Human RNase 7: a new cationic ribonuclease of the RNase A superfamily.

Authors: Jianzhi Zhang; Kimberly D Dyer; Helene F Rosenberg
Journal: Nucleic Acids Res Date: 2003-01-15 Impact factor: 16.971

20 in total

Review 1. RNase A ribonucleases and host defense: an evolving story.

Authors: Helene F Rosenberg
Journal: J Leukoc Biol Date: 2008-01-22 Impact factor: 4.962

Review 2. Midkine in host defence.

Authors: A Gela; S Jovic; S L Nordin; A Egesten
Journal: Br J Pharmacol Date: 2014-02 Impact factor: 8.739

Review 3. Functional roles of the human ribonuclease A superfamily in RNA metabolism and membrane receptor biology.

Authors: Heng-Huan Lee; Ying-Nai Wang; Mien-Chie Hung
Journal: Mol Aspects Med Date: 2019-03-25

4. Mouse beta-defensin-14, an antimicrobial ortholog of human beta-defensin-3.

Authors: Kerstin Hinrichsen; Rainer Podschun; Sabine Schubert; Jens M Schröder; Jürgen Harder; Ehrhardt Proksch
Journal: Antimicrob Agents Chemother Date: 2008-03-10 Impact factor: 5.191

5. Expression and function of human ribonuclease 4 in the kidney and urinary tract.

Authors: Kristin Bender; Laura L Schwartz; Ariel Cohen; Claudia Mosquera Vasquez; Matthew J Murtha; Tad Eichler; Jason P Thomas; Ashley Jackson; John David Spencer
Journal: Am J Physiol Renal Physiol Date: 2021-04-05

Review 6. RNase 7 in Cutaneous Defense.

Authors: Franziska Rademacher; Maren Simanski; Jürgen Harder
Journal: Int J Mol Sci Date: 2016-04-14 Impact factor: 5.923

7. RNase 7 contributes to the cutaneous defense against Enterococcus faecium.

Authors: Bente Köten; Maren Simanski; Regine Gläser; Rainer Podschun; Jens-Michael Schröder; Jürgen Harder
Journal: PLoS One Date: 2009-07-29 Impact factor: 3.240

8. In silico prediction and in vitro characterization of multifunctional human RNase3.

Authors: Pei-Chun Lien; Ping-Hsueh Kuo; Chien-Jung Chen; Hsiu-Hui Chang; Shun-lung Fang; Wei-Shuo Wu; Yiu-Kay Lai; Tun-Wen Pai; Margaret Dah-Tsyr Chang
Journal: Biomed Res Int Date: 2013-01-17 Impact factor: 3.411

9. Human antimicrobial peptides and proteins.

Authors: Guangshun Wang
Journal: Pharmaceuticals (Basel) Date: 2014-05-13

10. Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract.

Authors: Brian Becknell; Tad E Eichler; Susana Beceiro; Birong Li; Robert S Easterling; Ashley R Carpenter; Cindy L James; Kirk M McHugh; David S Hains; Santiago Partida-Sanchez; John D Spencer
Journal: Kidney Int Date: 2014-07-30 Impact factor: 10.612