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Literature DB >> 16940122

Intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes.

Isabel García¹, Sofía Ballesta, Concepción Murillo, Evelio J Perea, Alvaro Pascual.

Abstract

The intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes have been evaluated. DX-619 reached intracellular concentrations 10 times higher than the extracellular concentrations reached. Uptake was rapid, reversible, nonsaturable, and affected by environmental temperature, some metabolic inhibitors, and a soluble membrane activator. DX-619 showed intracellular activity against Staphylococcus aureus.

Entities: Chemical Species

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Year: 2006 PMID： 16940122 PMCID： PMC1563540 DOI： 10.1128/AAC.00427-06

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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References

17 in total

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Authors: Katsuko Fujikawa; Megumi Chiba; Mayumi Tanaka; Kenichi Sato
Journal: Antimicrob Agents Chemother Date: 2005-07 Impact factor: 5.191

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Journal: Antimicrob Agents Chemother Date: 2006-01 Impact factor: 5.191

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Journal: Antimicrob Agents Chemother Date: 2006-02 Impact factor: 5.191

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Authors: Jacob Strahilevitz; Que Chi Truong-Bolduc; David C Hooper
Journal: Antimicrob Agents Chemother Date: 2005-12 Impact factor: 5.191

Intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes.

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