Literature DB >> 11036051

Intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes.

I García1, A Pascual, S Ballesta, P Joyanes, E J Perea.   

Abstract

The intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes (PMN) were evaluated. Gemifloxacin reached intracellular concentrations eight times higher than extracellular concentrations. The uptake was rapid, reversible, and nonsaturable and was affected by environmental temperature, cell viability, and membrane stimuli. At therapeutic extracellular concentrations, gemifloxacin showed intracellular activity against Staphylococcus aureus.

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Year:  2000        PMID： 11036051      PMCID： PMC101631          DOI： 10.1128/AAC.44.11.3193-3195.2000

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  Activity of gemifloxacin against penicillin- and ciprofloxacin-resistant Streptococcus pneumoniae displaying topoisomerase- and efflux-mediated resistance mechanisms.

Authors:  V J Heaton; C E Goldsmith; J E Ambler; L M Fisher
Journal:  Antimicrob Agents Chemother       Date:  1999-12       Impact factor: 5.191

2.  In vitro and in vivo evaluations of LB20304, a new fluoronaphthyridone.

Authors:  J I Oh; K S Paek; M J Ahn; M Y Kim; C Y Hong; I C Kim; J H Kwak
Journal:  Antimicrob Agents Chemother       Date:  1996-06       Impact factor: 5.191

3.  Fluorometric and high-performance liquid chromatographic measurement of quinolone uptake by human neutrophils.

Authors:  A Pascual; I García; M C Conejo; E J Perea
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1991-11       Impact factor: 3.267

4.  Mechanisms of fluoroquinolone transport by human neutrophils.

Authors:  J D Walters; F Zhang; R J Nakkula
Journal:  Antimicrob Agents Chemother       Date:  1999-11       Impact factor: 5.191

5.  Fluorometric measurement of ofloxacin uptake by human polymorphonuclear leukocytes.

Authors:  A Pascual; I Garcia; E J Perea
Journal:  Antimicrob Agents Chemother       Date:  1989-05       Impact factor: 5.191

6.  Uptake and intracellular activity of sparfloxacin in human polymorphonuclear leukocytes and tissue culture cells.

Authors:  I García; A Pascual; M C Guzman; E J Perea
Journal:  Antimicrob Agents Chemother       Date:  1992-05       Impact factor: 5.191

7.  Entry of lomefloxacin and temafloxacin into human neutrophils, peritoneal macrophages, and tissue culture cells.

Authors:  A Pascual; I Garcia; E J Perea
Journal:  Diagn Microbiol Infect Dis       Date:  1992-07       Impact factor: 2.803

8.  Intracellular penetration and activity of BAY Y 3118 in human polymorphonuclear leukocytes.

Authors:  I García; A Pascual; E J Perea
Journal:  Antimicrob Agents Chemother       Date:  1994-10       Impact factor: 5.191

9.  Uptake and intracellular activity of an optically active ofloxacin isomer in human neutrophils and tissue culture cells.

Authors:  A Pascual; I Garcia; E J Perea
Journal:  Antimicrob Agents Chemother       Date:  1990-02       Impact factor: 5.191

10.  Uptake and activity of rifapentine in human peritoneal macrophages and polymorphonuclear leukocytes.

Authors:  A Pascual; D Tsukayama; J Kovarik; G Gekker; P Peterson
Journal:  Eur J Clin Microbiol       Date:  1987-04       Impact factor: 3.267
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  4 in total

1.  Intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes.

Authors:  Isabel García; Sofía Ballesta; Concepción Murillo; Evelio J Perea; Alvaro Pascual
Journal:  Antimicrob Agents Chemother       Date:  2006-09       Impact factor: 5.191

2.  Concentrations of gemifloxacin at the target site in healthy volunteers after a single oral dose.

Authors:  Florian Islinger; Rene Bouw; Mathias Stahl; Edith Lackner; Petra Zeleny; Martin Brunner; Markus Müller; Hans Georg Eichler; Christian Joukhadar
Journal:  Antimicrob Agents Chemother       Date:  2004-11       Impact factor: 5.191

3.  In vitro activity of gemifloxacin (SB-265805, LB20304a) against Legionella pneumophila and its pharmacokinetics in guinea pigs with L. pneumophila pneumonia.

Authors:  P H Edelstein; T Shinzato; E Doyle; M A Edelstein
Journal:  Antimicrob Agents Chemother       Date:  2001-08       Impact factor: 5.191

4.  Intracellular Accumulation of Novel and Clinically Used TB Drugs Potentiates Intracellular Synergy.

Authors:  Lloyd Tanner; Gabriel T Mashabela; Charles C Omollo; Timothy J de Wet; Christopher J Parkinson; Digby F Warner; Richard K Haynes; Lubbe Wiesner
Journal:  Microbiol Spectr       Date:  2021-09-29
  4 in total

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