| Literature DB >> 24109213 |
Tri Komala Sari1, Suzanne M Pritchard, Cristina W Cunha, George A Wudiri, Elizabeth I Laws, Hector C Aguilar, Naomi S Taus, Anthony V Nicola.
Abstract
Herpes simplex virus (HSV) proteins specifically required for endocytic entry but not direct penetration have not been identified. HSVs deleted of gE, gG, gI, gJ, gM, UL45, or Us9 entered cells via either pH-dependent or pH-independent endocytosis and were inactivated by mildly acidic pH. Thus, the required HSV glycoproteins, gB, gD, and gH-gL, may be sufficient for entry regardless of entry route taken. This may be distinct from entry mechanisms employed by other human herpesviruses.Entities:
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Year: 2013 PMID： 24109213 PMCID： PMC3838226 DOI： 10.1128/JVI.02500-13
Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103