BACKGROUND: The current study focuses on the prognostic value of pretreatment metabolic activity in metastases as measured with [(18)F]fluorodeoxyglucose positron emission tomography (FDG-PET), as an indicator of survival in colorectal cancer. PATIENTS AND METHODS: In a prospective series of 152 patients with metastatic colorectal cancer, of whom 67 were treated with resection of metastases and 85 with chemotherapy, standardized uptake values (SUV) as measured with FDG-PET, were calculated prior to treatment. Survival probabilities were estimated by Cox proportional regression analysis. For Kaplan-Meier analysis SUV was stratified by the median value. Survival differences were assessed using the log-rank test. RESULTS: SUV in metastases was a significant predictor for overall survival (hazard ratio 1.17, 95% confidence interval 1.06-1.30, P = 0.002), independent of the subsequent treatment. According to the median value of the patient population a low (SUV <4.26) and high uptake group (SUV >4.26) was defined. The median survival and the 2- and 3-year survival rates were 32 months, 59% and 45%, respectively, in the low-uptake group and 19 months, 37% and 28%, respectively, in the high-uptake group (P = 0.017). CONCLUSION: A significant survival benefit was observed in patients with low FDG uptake in metastases of colorectal cancer.
BACKGROUND: The current study focuses on the prognostic value of pretreatment metabolic activity in metastases as measured with [(18)F]fluorodeoxyglucose positron emission tomography (FDG-PET), as an indicator of survival in colorectal cancer. PATIENTS AND METHODS: In a prospective series of 152 patients with metastatic colorectal cancer, of whom 67 were treated with resection of metastases and 85 with chemotherapy, standardized uptake values (SUV) as measured with FDG-PET, were calculated prior to treatment. Survival probabilities were estimated by Cox proportional regression analysis. For Kaplan-Meier analysis SUV was stratified by the median value. Survival differences were assessed using the log-rank test. RESULTS: SUV in metastases was a significant predictor for overall survival (hazard ratio 1.17, 95% confidence interval 1.06-1.30, P = 0.002), independent of the subsequent treatment. According to the median value of the patient population a low (SUV <4.26) and high uptake group (SUV >4.26) was defined. The median survival and the 2- and 3-year survival rates were 32 months, 59% and 45%, respectively, in the low-uptake group and 19 months, 37% and 28%, respectively, in the high-uptake group (P = 0.017). CONCLUSION: A significant survival benefit was observed in patients with low FDG uptake in metastases of colorectal cancer.
Authors: Gustavo S P Meirelles; Heiko Schöder; Gregory C Ravizzini; Mithat Gönen; Josef J Fox; John Humm; Michael J Morris; Howard I Scher; Steven M Larson Journal: Clin Cancer Res Date: 2010-10-25 Impact factor: 12.531
Authors: Minsig Choi; Sri Lakshmi S Kollepara; Lance K Heilbrun; Daryn Smith; Anthony F Shields; Philip A Philip Journal: Clin Colorectal Cancer Date: 2014-10-23 Impact factor: 4.481
Authors: Linda Heijmen; Lioe-Fee de Geus-Oei; Johannes H W de Wilt; Dimitris Visvikis; Mathieu Hatt; Eric P Visser; Johan Bussink; Cornelis J A Punt; Wim J G Oyen; Hanneke W M van Laarhoven Journal: Eur J Nucl Med Mol Imaging Date: 2012-09-04 Impact factor: 9.236
Authors: J P B O'Connor; C J Rose; A Jackson; Y Watson; S Cheung; F Maders; B J Whitcher; C Roberts; G A Buonaccorsi; G Thompson; A R Clamp; G C Jayson; G J M Parker Journal: Br J Cancer Date: 2011-06-14 Impact factor: 7.640