Literature DB >> 16935753

Modern agrochemical research: a missed opportunity for drug discovery?

John Delaney1, Eric Clarke, David Hughes, Martin Rice.   

Abstract

The word "agrochemical" has often taken on a pejorative character in the public mind. Some of the negative tone might have coloured the perception of the industry by pharma, together with views on the chemical nature of agrochemicals that seem to be based on older pesticides that date back to the 1950s and 1960s. In this review, we try to address some of these concerns, draw out the similarities between agrochemical and pharmaceutical research and highlight opportunities for drug discovery that are offered by pesticide-related compounds, particularly with regard to herbicides and compounds with leadlike physical properties.

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Year:  2006        PMID: 16935753     DOI: 10.1016/j.drudis.2006.07.002

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN: 1359-6446            Impact factor:   7.851


  15 in total

Review 1.  Evaluation of machine-learning methods for ligand-based virtual screening.

Authors:  Beining Chen; Robert F Harrison; George Papadatos; Peter Willett; David J Wood; Xiao Qing Lewell; Paulette Greenidge; Nikolaus Stiefl
Journal:  J Comput Aided Mol Des       Date:  2007-01-05       Impact factor: 3.686

2.  The fixation of locally beneficial alleles in a metapopulation.

Authors:  Séverine Vuilleumier; Jon M Yearsley; Nicolas Perrin
Journal:  Genetics       Date:  2008-01       Impact factor: 4.562

Review 3.  α-Aminoazoles/azines: key reaction partners for multicomponent reactions.

Authors:  Shah Imtiaz; Jahangir Ahmad War; Syqa Banoo; Sarfaraz Khan
Journal:  RSC Adv       Date:  2021-03-16       Impact factor: 3.361

4.  The Soil Microbiota Recovery in the Agroecosystem: Minimal Information and a New Framework for Sustainable Agriculture.

Authors:  Alessandro Bergna; Stephen J Maund; Claudio Screpanti
Journal:  Int J Environ Res Public Health       Date:  2022-04-29       Impact factor: 4.614

5.  The yeast three-hybrid system as an experimental platform to identify proteins interacting with small signaling molecules in plant cells: potential and limitations.

Authors:  Stéphanie Cottier; Timon Mönig; Zheming Wang; Jiří Svoboda; Wilhelm Boland; Markus Kaiser; Erich Kombrink
Journal:  Front Plant Sci       Date:  2011-12-26       Impact factor: 5.753

Review 6.  The yeast two-hybrid and related methods as powerful tools to study plant cell signalling.

Authors:  Elisa Ferro; Lorenza Trabalzini
Journal:  Plant Mol Biol       Date:  2013-06-21       Impact factor: 4.335

7.  Quantitative estimation of pesticide-likeness for agrochemical discovery.

Authors:  Sorin Avram; Simona Funar-Timofei; Ana Borota; Sridhar Rao Chennamaneni; Anil Kumar Manchala; Sorel Muresan
Journal:  J Cheminform       Date:  2014-09-12       Impact factor: 5.514

8.  Herbicidal properties of antimalarial drugs.

Authors:  Maxime G Corral; Julie Leroux; Keith A Stubbs; Joshua S Mylne
Journal:  Sci Rep       Date:  2017-03-31       Impact factor: 4.379

9.  Investigating the spectrum of biological activity of substituted quinoline-2-carboxamides and their isosteres.

Authors:  Tomas Gonec; Pavel Bobal; Josef Sujan; Matus Pesko; Jiahui Guo; Katarina Kralova; Lenka Pavlacka; Libor Vesely; Eva Kreckova; Jiri Kos; Aidan Coffey; Peter Kollar; Ales Imramovsky; Lukas Placek; Josef Jampilek
Journal:  Molecules       Date:  2012-01-10       Impact factor: 4.411

10.  Synthesis and antimycobacterial and photosynthesis-inhibiting evaluation of 2-[(E)-2-substituted-ethenyl]-1,3-benzoxazoles.

Authors:  Ales Imramovsky; Jan Kozic; Matus Pesko; Jirina Stolarikova; Jarmila Vinsova; Katarina Kralova; Josef Jampilek
Journal:  ScientificWorldJournal       Date:  2014-08-13
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