OBJECTIVE: To assess the effect of chronic deconditioning on cardiac dimensions and function in subjects with high-level spinal cord injury (SCI), who represent a human in-vivo model of extreme inactivity. DESIGN: Cross-sectional study. SETTING: University medical center. PARTICIPANTS: Seven men with tetraplegia and 7 able-bodied controls. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Echocardiographic measurements of resting cardiac dimensions, systolic function, and global and long-axis diastolic function. RESULTS: Left ventricular mass index was significantly lower in the subjects with SCI than in the controls (90.8+/-26 g/m(2) vs 122+/-28.9 g/m(2); P=.05). In addition, dimensions of left ventricle, left atrium, and vena cava inferior were all significantly reduced in the subjects with SCI compared with controls (P<.05). There were no differences between the groups for any of the parameters reflecting systolic and global and long-axis diastolic function. CONCLUSIONS: Tetraplegia is associated with a reduction in cardiac mass and dimensions. Resting diastolic and systolic function is not altered with continued exposure to inactivity, however, which suggests a remodeling of the heart as a physiologic adaptive process.
OBJECTIVE: To assess the effect of chronic deconditioning on cardiac dimensions and function in subjects with high-level spinal cord injury (SCI), who represent a human in-vivo model of extreme inactivity. DESIGN: Cross-sectional study. SETTING: University medical center. PARTICIPANTS: Seven men with tetraplegia and 7 able-bodied controls. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Echocardiographic measurements of resting cardiac dimensions, systolic function, and global and long-axis diastolic function. RESULTS: Left ventricular mass index was significantly lower in the subjects with SCI than in the controls (90.8+/-26 g/m(2) vs 122+/-28.9 g/m(2); P=.05). In addition, dimensions of left ventricle, left atrium, and vena cava inferior were all significantly reduced in the subjects with SCI compared with controls (P<.05). There were no differences between the groups for any of the parameters reflecting systolic and global and long-axis diastolic function. CONCLUSIONS:Tetraplegia is associated with a reduction in cardiac mass and dimensions. Resting diastolic and systolic function is not altered with continued exposure to inactivity, however, which suggests a remodeling of the heart as a physiologic adaptive process.
Authors: Monira I Aldhahi; Andrew A Guccione; Lisa M K Chin; Joshua Woolstenhulme; Randall E Keyser Journal: Eur J Appl Physiol Date: 2019-11-07 Impact factor: 3.078
Authors: Christopher R West; Mark A Crawford; Malihe-Sadat Poormasjedi-Meibod; Katharine D Currie; Andre Fallavollita; Violet Yuen; John H McNeill; Andrei V Krassioukov Journal: J Physiol Date: 2014-02-17 Impact factor: 5.182
Authors: Dian J Cao; Nan Jiang; Andrew Blagg; Janet L Johnstone; Raj Gondalia; Misook Oh; Xiang Luo; Kai-Chun Yang; John M Shelton; Beverly A Rothermel; Thomas G Gillette; Gerald W Dorn; Joseph A Hill Journal: J Am Heart Assoc Date: 2013-04-08 Impact factor: 5.501