Literature DB >> 16930045

Studies on the synthesis of quartromicins a(3) and d(3): synthesis of the vertical and horizontal bis-spirotetronate fragments.

Tony K Trullinger1, Jun Qi, William R Roush.   

Abstract

Syntheses of the vertical (3) and horizontal (4) bis-spirotetronate units of quartromicins A3 and D3 are described, along with an efficient synthesis of alpha-hydroxy aldehyde exo-8b, a precursor to the exo-spirotetronate fragments 19 and 21.

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Year:  2006        PMID： 16930045      PMCID： PMC2593838          DOI： 10.1021/jo061059c

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  6 in total

1.  Partial stereochemical assignment of quartromicins A3 and D3.

Authors:  William R Roush; David A Barda
Journal:  Org Lett       Date:  2002-05-02       Impact factor: 6.005

2.  Toward the Development of a General Chiral Auxiliary. A Remarkable, Highly Diastereoselective, Auxiliary-Mediated Substitution: Application to an Enantioselective Synthesis of the Cyclohexene Subunit of (+)-Tetronolide.

Authors:  Robert K. Boeckman; Stephen T. Wrobleski
Journal:  J Org Chem       Date:  1996-10-18       Impact factor: 4.354

3.  Stereoselective epoxidations of acyclic allylic alcohols by transition metal--hydroperoxide reagents. Synthesis of dl-C18 Cecropia juvenile hormone from farnesol.

Authors:  S Tanaka; H Yamamoto; H Nozaki; K B Sharpless; R C Michaelson; J D Cutting
Journal:  J Am Chem Soc       Date:  1974-08-07       Impact factor: 15.419

4.  Synthesis of precursors of the agalacto (exo) fragment of the quartromicins via an auxiliary-controlled exo-selective Diels-Alder reaction.

Authors:  Jun Qi; William R Roush
Journal:  Org Lett       Date:  2006-06-22       Impact factor: 6.005

5.  Diastereoselective synthesis of the endo- and exo-spirotetronate subunits of the quartromicins. The first enantioselective Diels-Alder reaction of an acyclic (Z)-1,3-diene.

Authors:  William R Roush; Chris Limberakis; Roxanne K Kunz; David A Barda
Journal:  Org Lett       Date:  2002-05-02       Impact factor: 6.005

6.  Quartromicin, a complex of novel antiviral antibiotics. I. Production, isolation, physico-chemical properties and antiviral activity.

Authors:  M Tsunakawa; O Tenmyo; K Tomita; N Naruse; C Kotake; T Miyaki; M Konishi; T Oki
Journal:  J Antibiot (Tokyo)       Date:  1992-02       Impact factor: 2.649
  6 in total
  2 in total

1.  Synthesis of precursors of the agalacto (exo) fragment of the quartromicins via an auxiliary-controlled exo-selective Diels-Alder reaction.

Authors:  Jun Qi; William R Roush
Journal:  Org Lett       Date:  2006-06-22       Impact factor: 6.005

Review 2.  Spirotetronate polyketides as leads in drug discovery.

Authors:  Michelle H Lacoske; Emmanuel A Theodorakis
Journal:  J Nat Prod       Date:  2014-12-01       Impact factor: 4.050
  2 in total

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