Literature DB >> 1313409

Quartromicin, a complex of novel antiviral antibiotics. I. Production, isolation, physico-chemical properties and antiviral activity.

M Tsunakawa1, O Tenmyo, K Tomita, N Naruse, C Kotake, T Miyaki, M Konishi, T Oki.   

Abstract

A strain of Amycolatopsis orientalis No. Q427-8 (ATCC 53884) was found to produce a complex of new antiviral antibiotics, quartromicin which consisted of at least six components A1, A2, A3, D1, D2 and D3. Structural studies suggested that they are a novel type of molecules unrelated to any known antibiotics. Each component of quartromicin exhibited antiviral activity against herpes simplex virus type 1, influenza virus type A and human immunodeficiency virus.

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Year:  1992        PMID： 1313409     DOI： 10.7164/antibiotics.45.180

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  8 in total

Review 1.  Natural [4 + 2]-Cyclases.

Authors:  Byung-Sun Jeon; Shao-An Wang; Mark W Ruszczycky; Hung-Wen Liu
Journal:  Chem Rev       Date:  2016-12-01       Impact factor: 60.622

2.  Studies on the synthesis of quartromicins a(3) and d(3): synthesis of the vertical and horizontal bis-spirotetronate fragments.

Authors:  Tony K Trullinger; Jun Qi; William R Roush
Journal:  J Org Chem       Date:  2006-09-01       Impact factor: 4.354

3.  Synthesis of precursors of the agalacto (exo) fragment of the quartromicins via an auxiliary-controlled exo-selective Diels-Alder reaction.

Authors:  Jun Qi; William R Roush
Journal:  Org Lett       Date:  2006-06-22       Impact factor: 6.005

4.  The genus Amycolatopsis: Indigenous plasmids, cloning vectors and gene transfer systems.

Authors:  S Malhotra; R Lal
Journal:  Indian J Microbiol       Date:  2007-06-14       Impact factor: 2.461

Review 5.  Spirotetronate polyketides as leads in drug discovery.

Authors:  Michelle H Lacoske; Emmanuel A Theodorakis
Journal:  J Nat Prod       Date:  2014-12-01       Impact factor: 4.050

6.  Biosynthesis of versipelostatin: identification of an enzyme-catalyzed [4+2]-cycloaddition required for macrocyclization of spirotetronate-containing polyketides.

Authors:  Takuya Hashimoto; Junko Hashimoto; Kuniko Teruya; Takashi Hirano; Kazuo Shin-ya; Haruo Ikeda; Hung-wen Liu; Makoto Nishiyama; Tomohisa Kuzuyama
Journal:  J Am Chem Soc       Date:  2015-01-05       Impact factor: 15.419

7.  High-Throughput Screening and Molecular Dynamics Simulation of Natural Products for the Identification of Anticancer Agents against MCM7 Protein.

Authors:  Xin Zhang; Hui Chen; Hui Lin; Ronglan Wen; Fan Yang
Journal:  Appl Bionics Biomech       Date:  2022-09-15       Impact factor: 1.664

8.  Wychimicins, a new class of spirotetronate polyketides from Actinocrispum wychmicini MI503-A4.

Authors:  Tomoyuki Kimura; Maya Umekita; Masaki Hatano; Chigusa Hayashi; Ryuichi Sawa; Masayuki Igarashi
Journal:  J Antibiot (Tokyo)       Date:  2022-09-07       Impact factor: 3.424
  8 in total

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