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Literature DB >> 16925946

Balance of Yin and Yang: ubiquitylation-mediated regulation of p53 and c-Myc.

Mu-Shui Dai¹, Yetao Jin, Jayme R Gallegos, Hua Lu.

Abstract

Protein ubiquitylation has been demonstrated to play a vital role not only in mediating protein turnover but also in modulating protein activity. The stability and activity of the tumor suppressor p53 and of the oncoprotein c-Myc are no exception. Both are regulated through independent ubiquitylation by several E3 ubiquitin ligases. Interestingly, p53 and c-Myc are functionally connected by some of these E3 enzymes and their regulator ARF, although these proteins play opposite roles in controlling cell growth and proliferation. The balance of this complex ubiquitylation network and its disruption during oncogenesis will be the topics of this review.

Entities: Disease Gene

Mesh：

Substances：

Year: 2006 PMID： 16925946 PMCID： PMC1601943 DOI： 10.1593/neo.06334

Source DB: PubMed Journal: Neoplasia ISSN： 1476-5586 Impact factor: 5.715

245 in total

Review 1. Transcriptional repression by Myc.

Authors: Michael Wanzel; Steffi Herold; Martin Eilers
Journal: Trends Cell Biol Date: 2003-03 Impact factor: 20.808

2. p53 has a direct apoptogenic role at the mitochondria.

Authors: Motohiro Mihara; Susan Erster; Alexander Zaika; Oleksi Petrenko; Thomas Chittenden; Petr Pancoska; Ute M Moll
Journal: Mol Cell Date: 2003-03 Impact factor: 17.970

3. Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation.

Authors: Roger P Leng; Yunping Lin; Weili Ma; Hong Wu; Benedicte Lemmers; Stephen Chung; John M Parant; Guillermina Lozano; Razqallah Hakem; Samuel Benchimol
Journal: Cell Date: 2003-03-21 Impact factor: 41.582

4. Skp2 regulates Myc protein stability and activity.

Authors: So Young Kim; Andreas Herbst; Kathryn A Tworkowski; Simone E Salghetti; William P Tansey
Journal: Mol Cell Date: 2003-05 Impact factor: 17.970

5. Critical role for a central part of Mdm2 in the ubiquitylation of p53.

Authors: Erik Meulmeester; Ruth Frenk; Robert Stad; Petra de Graaf; Jean-Christophe Marine; Karen H Vousden; Aart G Jochemsen
Journal: Mol Cell Biol Date: 2003-07 Impact factor: 4.272

6. Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

Authors: Steven R Grossman; Maria E Deato; Chrystelle Brignone; Ho Man Chan; Andrew L Kung; Hideaki Tagami; Yoshihiro Nakatani; David M Livingston
Journal: Science Date: 2003-04-11 Impact factor: 47.728

7. Expression of the F-box protein SKP2 induces hyperplasia, dysplasia, and low-grade carcinoma in the mouse prostate.

Authors: Eun-Hee Shim; Linda Johnson; Hye-Lim Noh; Yoon-Jung Kim; Hong Sun; Caroline Zeiss; Hui Zhang
Journal: Cancer Res Date: 2003-04-01 Impact factor: 12.701

Review 8. Decision making by p53: life, death and cancer.

Authors: M Oren
Journal: Cell Death Differ Date: 2003-04 Impact factor: 15.828

9. The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription.

Authors: Natalie von der Lehr; Sara Johansson; Siqin Wu; Fuad Bahram; Alina Castell; Cihan Cetinkaya; Per Hydbring; Ingrid Weidung; Keiko Nakayama; Keiichi I Nakayama; Ola Söderberg; Tom K Kerppola; Lars-Gunnar Larsson
Journal: Mol Cell Date: 2003-05 Impact factor: 17.970

10. Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation.

Authors: Krishna P Bhat; Koji Itahana; Aiwen Jin; Yanping Zhang
Journal: EMBO J Date: 2004-05-20 Impact factor: 11.598

40 in total

1. Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation.

Authors: Mikael S Lindström; Aiwen Jin; Chad Deisenroth; Gabrielle White Wolf; Yanping Zhang
Journal: Mol Cell Biol Date: 2006-11-20 Impact factor: 4.272

2. The contribution of transactivation subdomains 1 and 2 to p53-induced gene expression is heterogeneous but not subdomain-specific.

Authors: Jennifer M Smith; Lawton J Stubbert; Jeffrey D Hamill; Bruce C McKay
Journal: Neoplasia Date: 2007-12 Impact factor: 5.715

Balance of Yin and Yang: ubiquitylation-mediated regulation of p53 and c-Myc.

Review 1. Transcriptional repression by Myc.

2. p53 has a direct apoptogenic role at the mitochondria.

3. Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation.

4. Skp2 regulates Myc protein stability and activity.

5. Critical role for a central part of Mdm2 in the ubiquitylation of p53.

6. Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

7. Expression of the F-box protein SKP2 induces hyperplasia, dysplasia, and low-grade carcinoma in the mouse prostate.

Review 8. Decision making by p53: life, death and cancer.

9. The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription.

10. Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation.

1. Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation.

2. The contribution of transactivation subdomains 1 and 2 to p53-induced gene expression is heterogeneous but not subdomain-specific.

Review 3. Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1.

4. β-Catenin-dependent FGF signaling sustains cell survival in the anterior embryonic head by countering Smad4.

Review 5. Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy.

6. Neoplasia: the second decade.

Review 7. ROS and p53: a versatile partnership.

8. The real face of juvenile polyposis syndrome.

9. Ribosomal protein S14 negatively regulates c-Myc activity.

Review 10. Signaling to p53: ribosomal proteins find their way.