Literature DB >> 16923949

Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy.

Chiatogu Onyewu1, Natalie A Afshari, Joseph Heitman.   

Abstract

In an established Candida albicans murine keratitis model, combination therapy with ophthalmic preparations of fluconazole and cyclosporine A (CsA) demonstrated in vivo drug synergy and effectively resolved wild-type C. albicans infection more rapidly than monotherapy with either drug. Calcineurin, the target of CsA, was also found to contribute to pathogenicity.

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Year:  2006        PMID： 16923949      PMCID： PMC1635197          DOI： 10.1128/AAC.00393-06

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  Spectrum of fungal keratitis at Wills Eye Hospital, Philadelphia, Pennsylvania.

Authors:  M A Tanure; E J Cohen; S Sudesh; C J Rapuano; P R Laibson
Journal:  Cornea       Date:  2000-05       Impact factor: 2.651

Review 2.  Fungal and parasitic infections of the eye.

Authors:  S A Klotz; C C Penn; G J Negvesky; S I Butrus
Journal:  Clin Microbiol Rev       Date:  2000-10       Impact factor: 26.132

3.  Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain.

Authors:  Teresa Bader; Klaus Schröppel; Stefan Bentink; Nina Agabian; Gerwald Köhler; Joachim Morschhäuser
Journal:  Infect Immun       Date:  2006-07       Impact factor: 3.441

Review 4.  Clinical, cellular, and molecular factors that contribute to antifungal drug resistance.

Authors:  T C White; K A Marr; R A Bowden
Journal:  Clin Microbiol Rev       Date:  1998-04       Impact factor: 26.132

Review 5.  Pharmacotherapy of fungal eye infections.

Authors:  B Manzouri; G C Vafidis; R K Wyse
Journal:  Expert Opin Pharmacother       Date:  2001-11       Impact factor: 3.889

6.  Practice guidelines for the treatment of candidiasis. Infectious Diseases Society of America.

Authors:  J H Rex; T J Walsh; J D Sobel; S G Filler; P G Pappas; W E Dismukes; J E Edwards
Journal:  Clin Infect Dis       Date:  2000-04-20       Impact factor: 9.079

7.  The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans.

Authors:  Chiatogu Onyewu; Floyd L Wormley; John R Perfect; Joseph Heitman
Journal:  Infect Immun       Date:  2004-12       Impact factor: 3.441

Review 8.  Current perspectives on ophthalmic mycoses.

Authors:  Philip A Thomas
Journal:  Clin Microbiol Rev       Date:  2003-10       Impact factor: 26.132

Review 9.  Fungal infections of the cornea.

Authors:  P A Thomas
Journal:  Eye (Lond)       Date:  2003-11       Impact factor: 3.775

10.  Isolation of the Candida albicans gene for orotidine-5'-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations.

Authors:  A M Gillum; E Y Tsay; D R Kirsch
Journal:  Mol Gen Genet       Date:  1984
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  18 in total

1.  In vitro interactions between antifungals and immunosuppressive drugs against zygomycetes.

Authors:  Eric Dannaoui; Patrick Schwarz; Olivier Lortholary
Journal:  Antimicrob Agents Chemother       Date:  2009-05-18       Impact factor: 5.191

2.  Dynamic duo takes down fungal villains.

Authors:  Camile P Semighini; Joseph Heitman
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-26       Impact factor: 11.205

Review 3.  Components of the calcium-calcineurin signaling pathway in fungal cells and their potential as antifungal targets.

Authors:  Shuyuan Liu; Yinglong Hou; Weiguo Liu; Chunyan Lu; Weixin Wang; Shujuan Sun
Journal:  Eukaryot Cell       Date:  2015-01-30

Review 4.  Direct effects of non-antifungal agents used in cancer chemotherapy and organ transplantation on the development and virulence of Candida and Aspergillus species.

Authors:  Sharon C-A Chen; Russell E Lewis; Dimitrios P Kontoyiannis
Journal:  Virulence       Date:  2011-07-01       Impact factor: 5.882

Review 5.  Dry eye disease and microbial keratitis: is there a connection?

Authors:  Srihari Narayanan; Rachel L Redfern; William L Miller; Kelly K Nichols; Alison M McDermott
Journal:  Ocul Surf       Date:  2013-01-29       Impact factor: 5.033

Review 6.  Signaling cascades as drug targets in model and pathogenic fungi.

Authors:  Robert J Bastidas; Jennifer L Reedy; Helena Morales-Johansson; Joseph Heitman; Maria E Cardenas
Journal:  Curr Opin Investig Drugs       Date:  2008-08

7.  Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence.

Authors:  Jennifer L Reedy; Scott G Filler; Joseph Heitman
Journal:  Fungal Genet Biol       Date:  2009-09-13       Impact factor: 3.495

8.  Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model.

Authors:  Chiatogu Onyewu; Emily Eads; Wiley A Schell; John R Perfect; Yehuda Ullmann; Gil Kaufman; Benjamin A Horwitz; Israela Berdicevsky; Joseph Heitman
Journal:  Antimicrob Agents Chemother       Date:  2007-07-30       Impact factor: 5.191

9.  Elongation factor 3, EF3, associates with the calcium channel Cch1 and targets Cch1 to the plasma membrane in Cryptococcus neoformans.

Authors:  Min Liu; Angie Gelli
Journal:  Eukaryot Cell       Date:  2008-05-23

10.  Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilms.

Authors:  Priya Uppuluri; Jeniel Nett; Joseph Heitman; David Andes
Journal:  Antimicrob Agents Chemother       Date:  2008-01-07       Impact factor: 5.191
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