Literature DB >> 16923916

Superoxide dismutase B gene (sodB)-deficient mutants of Francisella tularensis demonstrate hypersensitivity to oxidative stress and attenuated virulence.

Chandra Shekhar Bakshi1, Meenakshi Malik, Kevin Regan, J Andres Melendez, Dennis W Metzger, Vitaly M Pavlov, Timothy J Sellati.   

Abstract

A Francisella tularensis live vaccine strain mutant (sodB(Ft)) with reduced Fe-superoxide dismutase gene expression was generated and found to exhibit decreased sodB activity and increased sensitivity to redox cycling compounds compared to wild-type bacteria. The sodB(Ft) mutant also was significantly attenuated for virulence in mice. Thus, this study has identified sodB as an important F. tularensis virulence factor.

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Year:  2006        PMID： 16923916      PMCID： PMC1595384          DOI： 10.1128/JB.00266-06

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  30 in total

1.  Contribution of Mn-cofactored superoxide dismutase (SodA) to the virulence of Streptococcus agalactiae.

Authors:  C Poyart; E Pellegrini; O Gaillot; C Boumaila; M Baptista; P Trieu-Cuot
Journal:  Infect Immun       Date:  2001-08       Impact factor: 3.441

2.  Role and regulation of the superoxide dismutases of Staphylococcus aureus.

Authors:  Michail H Karavolos; Malcolm J Horsburgh; Eileen Ingham; Simon J Foster
Journal:  Microbiology       Date:  2003-10       Impact factor: 2.777

3.  Transcriptional and translational regulation of the marRAB multiple antibiotic resistance operon in Escherichia coli.

Authors:  Robert G Martin; Judah L Rosner
Journal:  Mol Microbiol       Date:  2004-07       Impact factor: 3.501

4.  The role of two periplasmic copper- and zinc-cofactored superoxide dismutases in the virulence of Salmonella choleraesuis.

Authors:  Assunta Sansone; Patricia R Watson; Timothy S Wallis; Paul R Langford; J Simon Kroll
Journal:  Microbiology       Date:  2002-03       Impact factor: 2.777

5.  Superoxide dismutase from escherichia coli B. A new manganese-containing enzyme.

Authors:  B B Keele; J M McCord; I Fridovich
Journal:  J Biol Chem       Date:  1970-11-25       Impact factor: 5.157

6.  Superoxide dismutase: improved assays and an assay applicable to acrylamide gels.

Authors:  C Beauchamp; I Fridovich
Journal:  Anal Biochem       Date:  1971-11       Impact factor: 3.365

7.  The contribution of reactive nitrogen and oxygen species to the killing of Francisella tularensis LVS by murine macrophages.

Authors:  Helena Lindgren; Linda Stenman; Arne Tärnvik; Anders Sjöstedt
Journal:  Microbes Infect       Date:  2005-02-26       Impact factor: 2.700

8.  Paraquat and Escherichia coli. Mechanism of production of extracellular superoxide radical.

Authors:  H M Hassan; I Fridovich
Journal:  J Biol Chem       Date:  1979-11-10       Impact factor: 5.157

9.  Increased expression of periplasmic Cu,Zn superoxide dismutase enhances survival of Escherichia coli invasive strains within nonphagocytic cells.

Authors:  A Battistoni; F Pacello; S Folcarelli; M Ajello; G Donnarumma; R Greco; M G Ammendolia; D Touati; G Rotilio; P Valenti
Journal:  Infect Immun       Date:  2000-01       Impact factor: 3.441

10.  A method for allelic replacement in Francisella tularensis.

Authors:  Igor Golovliov; Anders Sjöstedt; Alexander Mokrievich; Vitaly Pavlov
Journal:  FEMS Microbiol Lett       Date:  2003-05-28       Impact factor: 2.742
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  61 in total

1.  A Francisella tularensis live vaccine strain (LVS) mutant with a deletion in capB, encoding a putative capsular biosynthesis protein, is significantly more attenuated than LVS yet induces potent protective immunity in mice against F. tularensis challenge.

Authors:  Qingmei Jia; Bai-Yu Lee; Richard Bowen; Barbara Jane Dillon; Susan M Som; Marcus A Horwitz
Journal:  Infect Immun       Date:  2010-07-19       Impact factor: 3.441

2.  Development of tolerogenic dendritic cells and regulatory T cells favors exponential bacterial growth and survival during early respiratory tularemia.

Authors:  Sivakumar Periasamy; Anju Singh; Bikash Sahay; Tabassum Rahman; Paul J Feustel; Giang H Pham; Edmund J Gosselin; Timothy J Sellati
Journal:  J Leukoc Biol       Date:  2011-07-01       Impact factor: 4.962

3.  Resistance of Francisella tularensis strains against reactive nitrogen and oxygen species with special reference to the role of KatG.

Authors:  Helena Lindgren; Hua Shen; Carl Zingmark; Igor Golovliov; Wayne Conlan; Anders Sjöstedt
Journal:  Infect Immun       Date:  2007-01-08       Impact factor: 3.441

4.  Four superoxide dismutases contribute to Bacillus anthracis virulence and provide spores with redundant protection from oxidative stress.

Authors:  Robert J Cybulski; Patrick Sanz; Farhang Alem; Scott Stibitz; Robert L Bull; Alison D O'Brien
Journal:  Infect Immun       Date:  2008-10-27       Impact factor: 3.441

Review 5.  Tularemia vaccines.

Authors:  Daniela Putzova; Iva Senitkova; Jiri Stulik
Journal:  Folia Microbiol (Praha)       Date:  2016-05-19       Impact factor: 2.099

6.  SodA Contributes to the Virulence of Avian Pathogenic Escherichia coli O2 Strain E058 in Experimentally Infected Chickens.

Authors:  Qingqing Gao; Le Xia; Xiaobo Wang; Zhengqin Ye; Jinbiao Liu; Song Gao
Journal:  J Bacteriol       Date:  2019-02-25       Impact factor: 3.490

7.  Characterization of a Unique Outer Membrane Protein Required for Oxidative Stress Resistance and Virulence of Francisella tularensis.

Authors:  Maha Alqahtani; Zhuo Ma; Harshada Ketkar; Ragavan Varadharajan Suresh; Meenakshi Malik; Chandra Shekhar Bakshi
Journal:  J Bacteriol       Date:  2018-03-26       Impact factor: 3.490

Review 8.  Working toward the future: insights into Francisella tularensis pathogenesis and vaccine development.

Authors:  Roger D Pechous; Travis R McCarthy; Thomas C Zahrt
Journal:  Microbiol Mol Biol Rev       Date:  2009-12       Impact factor: 11.056

9.  An improved vaccine for prevention of respiratory tularemia caused by Francisella tularensis SchuS4 strain.

Authors:  Chandra Shekhar Bakshi; Meenakshi Malik; Manish Mahawar; Girish S Kirimanjeswara; Karsten R O Hazlett; Lance E Palmer; Martha B Furie; Rajendra Singh; J Andres Melendez; Timothy J Sellati; Dennis W Metzger
Journal:  Vaccine       Date:  2008-08-08       Impact factor: 3.641

10.  NaxD is a deacetylase required for lipid A modification and Francisella pathogenesis.

Authors:  Anna C Llewellyn; Jinshi Zhao; Feng Song; Jyothi Parvathareddy; Qian Xu; Brooke A Napier; Hamed Laroui; Didier Merlin; James E Bina; Peggy A Cotter; Mark A Miller; Christian R H Raetz; David S Weiss
Journal:  Mol Microbiol       Date:  2012-09-11       Impact factor: 3.501
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