Literature DB >> 16923791

Alpha-toxin of Clostridium perfringens is not an essential virulence factor in necrotic enteritis in chickens.

Anthony L Keyburn1, Scott A Sheedy, Mark E Ford, Mark M Williamson, Milena M Awad, Julian I Rood, Robert J Moore.   

Abstract

The Clostridium perfringens alpha-toxin has previously been implicated as the major virulence factor in necrotic enteritis in chickens, although definitive proof has not been reported. In this study an alpha-toxin mutant was constructed in a virulent chicken isolate and shown to retain full virulence in a chicken disease model. These results demonstrated that alpha-toxin is not an essential virulence factor in the pathogenesis of necrotic enteritis in chickens.

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Year:  2006        PMID： 16923791      PMCID： PMC1695520          DOI： 10.1128/IAI.00806-06

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  46 in total

1.  Synergistic effects of alpha-toxin and perfringolysin O in Clostridium perfringens-mediated gas gangrene.

Authors:  M M Awad; D M Ellemor; R L Boyd; J J Emmins; J I Rood
Journal:  Infect Immun       Date:  2001-12       Impact factor: 3.441

2.  The interaction of Clostridium perfringens and its toxins in the production of necrotic enteritis of chickens.

Authors:  F Al-Sheikhly; R B Truscott
Journal:  Avian Dis       Date:  1977 Apr-Jun       Impact factor: 1.577

3.  Prevalence of cpb2, encoding beta2 toxin, in Clostridium perfringens field isolates: correlation of genotype with phenotype.

Authors:  Dawn M Bueschel; B Helen Jost; Stephen J Billington; Hien T Trinh; J Glenn Songer
Journal:  Vet Microbiol       Date:  2003-07-01       Impact factor: 3.293

4.  A new method for the experimental production of necrotic enteritis and its use for studies on the relationships between necrotic enteritis, coccidiosis and anticoccidial vaccination of chickens.

Authors:  R B Williams; R N Marshall; R M La Ragione; J Catchpole
Journal:  Parasitol Res       Date:  2003-01-28       Impact factor: 2.289

5.  Molecular typing of isolates of Clostridium perfringens from healthy and diseased poultry.

Authors:  B E Engström; C Fermér; A Lindberg; E Saarinen; V Båverud; A Gunnarsson
Journal:  Vet Microbiol       Date:  2003-07-17       Impact factor: 3.293

6.  Analysis by pulsed-field gel electrophoresis of the genetic diversity among Clostridium perfringens isolates from chickens.

Authors:  B Nauerby; K Pedersen; M Madsen
Journal:  Vet Microbiol       Date:  2003-07-17       Impact factor: 3.293

7.  Immunohistochemical localization of Clostridium perfringens beta2-toxin in the gastrointestinal tract of horses.

Authors:  L N Bacciarini; P Boerlin; R Straub; J Frey; A Gröne
Journal:  Vet Pathol       Date:  2003-07       Impact factor: 2.221

8.  The influence of diet on necrotic enteritis in broiler chickens.

Authors:  C Riddell; X M Kong
Journal:  Avian Dis       Date:  1992 Jul-Sep       Impact factor: 1.577

9.  Genotyping and phenotyping of beta2-toxigenic Clostridium perfringens fecal isolates associated with gastrointestinal diseases in piglets.

Authors:  Michael Waters; Amanda Savoie; Helen S Garmory; Dawn Bueschel; Michel R Popoff; J Glenn Songer; Richard W Titball; Bruce A McClane; Mahfuzur R Sarker
Journal:  J Clin Microbiol       Date:  2003-08       Impact factor: 5.948

10.  A role for the Clostridium perfringens beta2 toxin in bovine enterotoxaemia?

Authors:  C Manteca; G Daube; T Jauniaux; A Linden; V Pirson; J Detilleux; A Ginter; P Coppe; A Kaeckenbeeck; J G Mainil
Journal:  Vet Microbiol       Date:  2002-05-01       Impact factor: 3.293
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  72 in total

1.  The VirSR two-component signal transduction system regulates NetB toxin production in Clostridium perfringens.

Authors:  Jackie K Cheung; Anthony L Keyburn; Glen P Carter; Anouk L Lanckriet; Filip Van Immerseel; Robert J Moore; Julian I Rood
Journal:  Infect Immun       Date:  2010-05-10       Impact factor: 3.441

2.  Multilocus sequence typing subtypes of poultry Clostridium perfringens isolates demonstrate disease niche partitioning.

Authors:  M C Hibberd; A P Neumann; T G Rehberger; G R Siragusa
Journal:  J Clin Microbiol       Date:  2011-01-26       Impact factor: 5.948

3.  Two putative zinc metalloproteases contribute to the virulence of Clostridium perfringens strains that cause avian necrotic enteritis.

Authors:  Ben Wade; Anthony L Keyburn; Volker Haring; Mark Ford; Julian I Rood; Robert J Moore
Journal:  J Vet Diagn Invest       Date:  2020-01-10       Impact factor: 1.279

4.  A live oral recombinant Salmonella enterica serovar typhimurium vaccine expressing Clostridium perfringens antigens confers protection against necrotic enteritis in broiler chickens.

Authors:  R R Kulkarni; V R Parreira; Y-F Jiang; J F Prescott
Journal:  Clin Vaccine Immunol       Date:  2009-12-09

5.  Expression profiles of genes in Toll-like receptor-mediated signaling of broilers infected with Clostridium perfringens.

Authors:  Yang Lu; Aimie J Sarson; Joshua Gong; Huaijun Zhou; Weiyun Zhu; Zhumei Kang; Hai Yu; Shayan Sharif; Yanming Han
Journal:  Clin Vaccine Immunol       Date:  2009-09-23

6.  Quantification of cell proliferation and alpha-toxin gene expression of Clostridium perfringens in the development of necrotic enteritis in broiler chickens.

Authors:  Weiduo Si; Joshua Gong; Yanming Han; Hai Yu; John Brennan; Huaijun Zhou; Shu Chen
Journal:  Appl Environ Microbiol       Date:  2007-09-07       Impact factor: 4.792

7.  Clostridium perfringens alpha-toxin recognizes the GM1a-TrkA complex.

Authors:  Masataka Oda; Michiko Kabura; Teruhisa Takagishi; Ayaka Suzue; Kaori Tominaga; Shiori Urano; Masahiro Nagahama; Keiko Kobayashi; Keiko Furukawa; Koichi Furukawa; Jun Sakurai
Journal:  J Biol Chem       Date:  2012-07-30       Impact factor: 5.157

8.  Functional analysis of a bacitracin resistance determinant located on ICECp1, a novel Tn916-like element from a conjugative plasmid in Clostridium perfringens.

Authors:  Xiaoyan Han; Xiang-Dang Du; Luke Southey; Dieter M Bulach; Torsten Seemann; Xu-Xia Yan; Trudi L Bannam; Julian I Rood
Journal:  Antimicrob Agents Chemother       Date:  2015-08-17       Impact factor: 5.191

9.  Identification of novel pathogenicity loci in Clostridium perfringens strains that cause avian necrotic enteritis.

Authors:  Dion Lepp; Bryan Roxas; Valeria R Parreira; Pradeep R Marri; Everett L Rosey; Joshua Gong; J Glenn Songer; Gayatri Vedantam; John F Prescott
Journal:  PLoS One       Date:  2010-05-24       Impact factor: 3.240

10.  Association between avian necrotic enteritis and Clostridium perfringens strains expressing NetB toxin.

Authors:  Anthony L Keyburn; Xu-Xia Yan; Trudi L Bannam; Filip Van Immerseel; Julian I Rood; Robert J Moore
Journal:  Vet Res       Date:  2009-11-25       Impact factor: 3.683
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