BACKGROUND: Capsule endoscopy (CE) is increasingly being used to investigate the small bowel for various indications, including obscure GI bleeding (OGB). However, false negatives have been described. Double-balloon enteroscopy (DBE) is a new endoscopic technique developed to potentially view the entire small intestine while allowing therapeutic options to be carried out when appropriate. OBJECTIVE: We described 4 patients with small-bowel pathology missed on CE but detected by DBE. DESIGN: Descriptive retrospective study. All patients underwent CE followed by DBE. SETTING: Single-center tertiary referral hospital. PATIENTS: Four patients were included. Three patients had OGB that required blood transfusions. One patient with celiac disease, compliant on a strict gluten-free diet for 5 months, presented with persistent weight loss and abdominal pain. INTERVENTIONS: DBE followed by surgical exploration and resection of small-bowel pathology. MAIN OUTCOME MEASUREMENTS: Successful identification of pathology missed by CE. Definitive treatment of small-bowel pathology by surgical resection. RESULTS: CE did not identify the small-bowel pathology in all 4 patients. The 3 patients with OGB had small-bowel masses found by DBE. Two of these were GI stromal tumors and one was an adenocarcinoma. The patient with celiac disease had a malignant ulcer, confirmed to be a lymphoma after surgical resection. LIMITATIONS: Retrospective study and small sample size. CONCLUSIONS: CE and DBE are complementary investigations. If there is a high index of suspicion of small-bowel pathology despite a negative CE, DBE should be performed.
BACKGROUND: Capsule endoscopy (CE) is increasingly being used to investigate the small bowel for various indications, including obscure GI bleeding (OGB). However, false negatives have been described. Double-balloon enteroscopy (DBE) is a new endoscopic technique developed to potentially view the entire small intestine while allowing therapeutic options to be carried out when appropriate. OBJECTIVE: We described 4 patients with small-bowel pathology missed on CE but detected by DBE. DESIGN: Descriptive retrospective study. All patients underwent CE followed by DBE. SETTING: Single-center tertiary referral hospital. PATIENTS: Four patients were included. Three patients had OGB that required blood transfusions. One patient with celiac disease, compliant on a strict gluten-free diet for 5 months, presented with persistent weight loss and abdominal pain. INTERVENTIONS: DBE followed by surgical exploration and resection of small-bowel pathology. MAIN OUTCOME MEASUREMENTS: Successful identification of pathology missed by CE. Definitive treatment of small-bowel pathology by surgical resection. RESULTS: CE did not identify the small-bowel pathology in all 4 patients. The 3 patients with OGB had small-bowel masses found by DBE. Two of these were GI stromal tumors and one was an adenocarcinoma. The patient with celiac disease had a malignant ulcer, confirmed to be a lymphoma after surgical resection. LIMITATIONS: Retrospective study and small sample size. CONCLUSIONS: CE and DBE are complementary investigations. If there is a high index of suspicion of small-bowel pathology despite a negative CE, DBE should be performed.
Authors: G Anton Decker; Jonathan A Leighton; M Edwyn Harrison; Cuong C Nguyen; Ananya Das; Shabana F Pasha; Adyr A Moss; Laurence J Miller Journal: Gastroenterol Hepatol (N Y) Date: 2007-12