Literature DB >> 16922648

Human P450s in the metabolism of drugs: molecular modelling of enzyme-substrate interactions.

David F V Lewis1.   

Abstract

The importance of cytochrome P450 enzymes to the Phase I metabolism of drugs and other xenobiotics is reviewed in the light of current knowledge. The relatively new technologies of molecular biology, protein crystallography and molecular modelling have been applied to these enzymes and this endeavour is proving extremely useful for novel compound development.

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Year:  2005        PMID： 16922648     DOI： 10.1517/17425255.1.1.5

Source DB:  PubMed          Journal:  Expert Opin Drug Metab Toxicol        ISSN： 1742-5255            Impact factor:   4.481


  4 in total

Review 1.  Substrate binding to cytochromes P450.

Authors:  Emre M Isin; F Peter Guengerich
Journal:  Anal Bioanal Chem       Date:  2008-07-13       Impact factor: 4.142

Review 2.  Hepatocyte nuclear factor 4alpha regulation of bile acid and drug metabolism.

Authors:  John Y L Chiang
Journal:  Expert Opin Drug Metab Toxicol       Date:  2009-02       Impact factor: 4.481

3.  The relationship between the bioactivation and detoxification of diazinon and chlorpyrifos, and the inhibition of acetylcholinesterase activity in Chirostoma jordani from three lakes with low to high organophosphate pesticides contamination.

Authors:  Ricardo Dzul-Caamal; M Lilia Domínguez-Lòpez; Hugo F Olivares-Rubio; Ethel García-Latorre; Armando Vega-López
Journal:  Ecotoxicology       Date:  2014-02-27       Impact factor: 2.823

Review 4.  Cytoprotection "gone astray": Nrf2 and its role in cancer.

Authors:  Claudia Geismann; Alexander Arlt; Susanne Sebens; Heiner Schäfer
Journal:  Onco Targets Ther       Date:  2014-08-26       Impact factor: 4.147
  4 in total

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