Literature DB >> 16920025

Pathogen-derived immunomodulatory molecules: future immunotherapeutics?

Padraic G Fallon1, Antonio Alcami.   

Abstract

The identification of molecules from various pathogens that modulate innate and/or adaptive immunity is a dynamic and rapidly developing area of research. These immunomodulatory molecules (IM) have been optimized during pathogen-host co-evolution, and have a potential application as novel immunotherapeutics. In this review, we illustrate the use of pathogen IM that have been produced as recombinant proteins, with different modes of modulatory activity, and discuss their potential to modulate undesirable immune responses in human diseases.

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Year:  2006        PMID： 16920025     DOI： 10.1016/j.it.2006.08.002

Source DB:  PubMed          Journal:  Trends Immunol        ISSN： 1471-4906            Impact factor:   16.687


  26 in total

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2.  An ectromelia virus protein that interacts with chemokines through their glycosaminoglycan binding domain.

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4.  Molecular and functional characterization of macrophage migration inhibitory factor (MIF) homolog of human from lymphatic filarial parasite Wuchereria bancrofti.

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Authors:  Jan Felix; Savvas N Savvides
Journal:  Nat Rev Immunol       Date:  2016-12-28       Impact factor: 53.106

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Journal:  Virology       Date:  2009-11-08       Impact factor: 3.616

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Authors:  Lucila G G Pacífico; Fábio A V Marinho; Cristina T Fonseca; Michele M Barsante; Vanessa Pinho; Policarpo A Sales-Junior; Luciana S Cardoso; Maria Ilma Araújo; Edgar M Carvalho; Geovanni D Cassali; Mauro M Teixeira; Sergio C Oliveira
Journal:  Infect Immun       Date:  2008-09-29       Impact factor: 3.441

9.  IgG glycan hydrolysis by a bacterial enzyme as a therapy against autoimmune conditions.

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Authors:  Mark Windheim; Stefan Höning; Keith N Leppard; Larissa Butler; Christina Seed; Sreenivasan Ponnambalam; Hans-Gerhard Burgert
Journal:  J Biol Chem       Date:  2016-02-03       Impact factor: 5.157
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