| Literature DB >> 16919856 |
Robin van Houdt1, Gerard J B Sonder, Nicole H T M Dukers, Lian P M J Bovee, Anneke van den Hoek, Roel A Coutinho, Sylvia M Bruisten.
Abstract
To evaluate hepatitis B virus (HBV) risk group vaccination in Amsterdam, which started in 1998, we examined 342 reported acute HBV-cases and sequenced 85 DNA isolates. The reported number of cases declined from 214 in 1992-1997 to 128 in 1998-2003, due to a decline in injecting drug users (IDU) and their heterosexual partners. Phylogenetic analyses showed that after 1998, the IDU cluster nearly disappeared, probably due to a decline in injecting. Acute HBV remained stable among men having sex with men; given their increased sexual risk behavior, vaccination has probably prevented an increase in their acute infections. Currently, 48-72% of the people who should be included in the program are still susceptible to HBV.Entities:
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Year: 2006 PMID： 16919856 DOI： 10.1016/j.vaccine.2006.06.058
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641