| Literature DB >> 16919608 |
Shuzhen Guo1, Sophia Wang, Woo Jean Kim, Sun-Ryung Lee, Matthew P Frosch, Brian J Bacskai, Steven M Greenberg, Eng H Lo.
Abstract
Matrix metalloproteinase-9 (MMP-9) may play a role in the inflammatory glial response during Alzheimer's disease (AD). Astrocytes can degrade beta-amyloid (Abeta) and extracellular proteolysis via MMP-9 may be involved. Because Apolipoprotein E (APOE) genotype is an important factor for AD, we ask whether various apoE isoforms can influence Abeta-induced MMP-9 responses in primary rat astrocytes. Our data show that apoE4 significantly dampens Abeta-induced MMP-9 levels, possibly by downregulating the Rho-Rho kinase (ROCK) pathway. Reduction of astrocytic MMP-9 by apoE4 may affect Abeta clearance and promote Abeta deposition in AD.Entities:
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Year: 2006 PMID： 16919608 DOI： 10.1016/j.brainres.2006.06.041
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252