| Literature DB >> 16919269 |
Peter J Bailey1, Joanna M Klos, Elisabet Andersson, Mattias Karlén, Magdalena Källström, Jasmina Ponjavic, Jonas Muhr, Boris Lenhard, Albin Sandelin, Johan Ericson.
Abstract
Highly conserved non-coding DNA regions (HCNR) occur frequently in vertebrate genomes, but their functional roles remain unclear. Here, we provide evidence that a large portion of HCNRs are enriched for binding sites for Sox, POU and Homeodomain transcription factors, and such HCNRs can act as cis-regulatory regions active in neural stem cells. Strikingly, these HCNRs are linked to several hundreds of genes expressed in the developing CNS and they may exert locus-wide regulatory effects on multiple genes flanking their genomic location. Moreover, these data imply a unifying transcriptional logic for a large set of CNS-expressed genes in which Sox and POU proteins act as generic promoters of transcription while Homeodomain proteins control the spatial expression of genes through active repression.Entities:
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Year: 2006 PMID： 16919269 DOI： 10.1016/j.yexcr.2006.06.017
Source DB: PubMed Journal: Exp Cell Res ISSN： 0014-4827 Impact factor: 3.905