Literature DB >> 1691865

Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing.

S S Sisodia1, E H Koo, K Beyreuther, A Unterbeck, D L Price.   

Abstract

The beta-amyloid protein (beta/A4), derived from a larger amyloid precursor protein (APP), is the principal component of senile plaques in Alzheimer's disease. APP is an integral membrane glycoprotein and is secreted as a carboxyl-terminal truncated molecule. APP cleavage, which is a membrane-associated event, occurred at a site located within the beta/A4 region. This suggests that an intact amyloidogenic beta/A4 fragment is not generated during normal APP catabolism. Therefore, an early event in amyloid formation may involve altered APP processing that results in the release and subsequent deposition of intact beta/A4.

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Year:  1990        PMID： 1691865     DOI： 10.1126/science.1691865

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  155 in total

1.  Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein.

Authors:  H Koike; S Tomioka; H Sorimachi; T C Saido; K Maruyama; A Okuyama; A Fujisawa-Sehara; S Ohno; K Suzuki; S Ishiura
Journal:  Biochem J       Date:  1999-10-15       Impact factor: 3.857

Review 2.  Caveolins, liquid-ordered domains, and signal transduction.

Authors:  E J Smart; G A Graf; M A McNiven; W C Sessa; J A Engelman; P E Scherer; T Okamoto; M P Lisanti
Journal:  Mol Cell Biol       Date:  1999-11       Impact factor: 4.272

3.  Apolipoprotein E forms stable complexes with recombinant Alzheimer's disease beta-amyloid precursor protein.

Authors:  C Haas; P Cazorla; C D Miguel; F Valdivieso; J Vázquez
Journal:  Biochem J       Date:  1997-07-01       Impact factor: 3.857

Review 4.  Alzheimer's disease.

Authors:  M Rossor
Journal:  Postgrad Med J       Date:  1992-07       Impact factor: 2.401

Review 5.  Amyloidosis in aging and Alzheimer's disease.

Authors:  D L Price; L C Walker; L J Martin; S S Sisodia
Journal:  Am J Pathol       Date:  1992-10       Impact factor: 4.307

Review 6.  Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells.

Authors:  Silke Brunholz; Sangram Sisodia; Alfredo Lorenzo; Carole Deyts; Stefan Kins; Gerardo Morfini
Journal:  Exp Brain Res       Date:  2011-09-30       Impact factor: 1.972

7.  Stimulated platelets release amyloid beta-protein precursor.

Authors:  G M Cole; D Galasko; I P Shapiro; T Saitoh
Journal:  Biochem Biophys Res Commun       Date:  1990-07-16       Impact factor: 3.575

Review 8.  Molecular and cellular mechanisms of ectodomain shedding.

Authors:  Kazutaka Hayashida; Allison H Bartlett; Ye Chen; Pyong Woo Park
Journal:  Anat Rec (Hoboken)       Date:  2010-06       Impact factor: 2.064

Review 9.  Distribution of beta/A4 protein and amyloid precursor protein in hereditary cerebral hemorrhage with amyloidosis-Dutch type and Alzheimer's disease.

Authors:  A J Rozemuller; R A Roos; G T Bots; W Kamphorst; P Eikelenboom; W E Van Nostrand
Journal:  Am J Pathol       Date:  1993-05       Impact factor: 4.307

10.  Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path.

Authors:  J D Buxbaum; G Thinakaran; V Koliatsos; J O'Callahan; H H Slunt; D L Price; S S Sisodia
Journal:  J Neurosci       Date:  1998-12-01       Impact factor: 6.167
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