Literature DB >> 16916876

The prevalence of sight-threatening uveitis in Scotland.

G J Williams1, S Brannan, J V Forrester, M P Gavin, S P Paterson-Brown, A T Purdie, M Virdi, J A Olson.   

Abstract

AIM: To identify and quantify the prevalence of patients with uveitis receiving systemic immunosuppression in Scotland.
METHODS: Anonymised data were prospectively collected on all patients with uveitis requiring systemic immunosuppression. Seven health boards participated over a 4-month period between 1 August 2005 and 30 November 2005.
RESULTS: 373 patients were identified, of whom 205 (55%) were female. The mean age was 46.4 (range 7-97 years). Using the data from the seven participating health boards, an estimated Scottish prevalence of 9 per 100 000 was calculated. Prevalence varied between 2 and 59 per 100 000. In National Health Service Grampian, all patients with uveitis, whether sight-threatening or not, are followed up at a specialist clinic. Extrapolating this figure to Scotland gives a prevalence of 25 per 100 000. DISCUSSION: The data from National Health Service Grampian suggest that there is a significant shortfall in the number of patients identified by survey. If the "missing population" exists, then where are they? Some might be receiving appropriate treatment at non-specialist clinics, although simple under-reporting may play a part. Greater concern is for those patients receiving inappropriate treatment for their uveitis, or for those within the community who are either oblivious to or in self denial of their condition.

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Mesh:

Year:  2006        PMID: 16916876      PMCID: PMC1857573          DOI: 10.1136/bjo.2006.101386

Source DB:  PubMed          Journal:  Br J Ophthalmol        ISSN: 0007-1161            Impact factor:   4.638


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  14 in total

Review 1.  Statins as anti-inflammatory agents: A potential therapeutic role in sight-threatening non-infectious uveitis.

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Journal:  Porto Biomed J       Date:  2017-03-01

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4.  Anti-tumour necrosis factor biological therapies for the treatment of uveitic macular oedema (UMO) for non-infectious uveitis.

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Journal:  Syst Rev       Date:  2016-02-13

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Authors:  Michael M Altaweel; Sapna S Gangaputra; Jennifer E Thorne; James P Dunn; Susan G Elner; Glenn J Jaffe; Rosa Y Kim; P Kumar Rao; Susan B Reed; John H Kempen
Journal:  J Ophthalmic Inflamm Infect       Date:  2016-09-09

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Authors:  Mohammad O Tallouzi; Jonathan M Mathers; David J Moore; Philip I Murray; Nicholas Bucknall; Jane M Blazeby; Melanie Calvert; Alastair K Denniston
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10.  Clinical Remission of Sight-Threatening Non-Infectious Uveitis Is Characterized by an Upregulation of Peripheral T-Regulatory Cell Polarized Towards T-bet and TIGIT.

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Journal:  Front Immunol       Date:  2018-05-03       Impact factor: 7.561

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